Paraneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review

David G. Morrison

doi:10.34257/GJMRAVOL23IS1PG27

Authors

David G. Morrison

Abstract

53-year-old lady presented with progressively worsening loss of voice. Over time she could only be heard upon speaking directly into the ears of her family or physicians. She lost her job as a receptionist due to her loss of voice. She was still on adjuvant treatment for breast cancer. She underwent CT/PET, ENT consultation and a battery of paraneoplastic antibody tests. ENT consultation confirmed vocal cord paralysis. ENT exam and CT/PET found no evidence of vocal cord mass or any lesion compressing the laryngeal nerves. No mass was found in the superior mediastinum. She had a positive antibody test for anti-acetylcholine receptors. Treatment with pyridostigmine reversed her vocal cord paralysis. This is the first report of a patient with breast cancer associated paraneoplastic myasthenia gravis syndrome.

Downloads

Article PDF

How to Cite

Paraneoplastic Syndrome of Myasthenia Gravis Presenting as Isolated Vocal Cord Paralysis in a Patient with Breast Cancer: Case Report and Literature Review. (2023). Global Journal of Medical Research, 23(A1), 27-28. https://doi.org/10.34257/GJMRAVOL23IS1PG27

Download Citation

References

S Kahan (2005) Unknown Title. 118.

Henry Kaminski (2009) Myasthenia Gravis and Related Disorders. 72.

Anita Mcgrogan, Samantha Sneddon, Corinne De Vries (2010) The Incidence of Myasthenia Gravis: A Systematic Literature Review. 34(3), 171-183.

W Xia, Huang (2007) R Dysphonia as a primary manifestation in myasthenia gravis (MG): A retrospective review of 7 cases among 1520 MG patients. 260, 16-22.

F Luliis, L Amoroso, ; Blair Unexpected vocal cord paralysis and Myasthenia Gravis in a patient with Squamous Cell Lung Cancer Case Report. 3, 2.

R Knudsen, M Gaunsbaek, J Shultz (2019) Vocal cord paralysis as primary and secondary results of malignancy: A prospective descriptive study. 4, 241-245.

Christopher Chang, Tereza Martinu, David Witsell (2004) Bilateral Vocal Cord Paresis as a Presenting Sign of Paraneoplastic Syndrome: Case Report. 130(6), 788-790.

J Debois, Txnxm (2002) The Anatomy and Clinics of Metastatic Cancer. 1, 199-200.

J Batsakis, M Luna (1985) Metastases to the larynx Head and. 7, 458-460.

A Ferlito, G Caruso, G Recher (1988) Secondary Laryngeal Tumors: Report of Seven Cases With Review of the Literature. 114(6), 635-639.

Piero Nicolai, Roberto Puxeddu, Johnny Cappiello, Giorgio Peretti, Simonetta Battocchio, Fabio Facchetti, Antonino Antonelli (1996) Metastatic Neoplasms to the Larynx: Report of Three Cases. 106(7), 851-855.

Kristin Henry (2019) Paraneoplastic syndromes: Definitions, classification, pathophysiology and principles of treatment. 36(4), 204-210.

M Li, F Ge, R Guo (2019) Do early prednisolone and other immunosuppressant therapies prevent generalization of ocular MG in Western populations: A review and meta-analysis. 12, 1-8.