Histological Features of Scar Tissue Formation in Different Methods of Postoperative Wound Closure

Abstract

The aim is to study the features of histological and morphometric changes of skin scars in different variants of soft tissue wound closure. Materials and methods: 60 Wistar rats, divided into 5 groups, were operated on: control group and 4 experimental ones: interrupted (loop) sutures, subcuticular suture, adhesion with dermal glue "Dermabond", interconnection with high freaquency electrocoagulator - HFEW. Skin regeneration and scar formation were studied with histological and morphometric methods on 7th and 14th day. Results: On the day 7 after the closure of the wound defect, the thickness of the perifocal epidermis was significantly increased by 1.5-2.4 times due to reepithelialization and the formation of granulation tissue. No morphological differences in skin regeneration after interrupted and subcuticular sutures were found. Application of "Dermabond" and HFEW caused progressive increase thickness of the epithelium.