Study of α-Amylase Inhibitory Activity of Fractions Purified by Chromatographic Methods of the Endophytic Fungus Penicillium Brevicaule Alba-CC200

Authors

  • Mukhammedov Iqbol

  • Gulyamova Tashkhan

  • Ruzieva Dilaram

  • Nasmetova Saodat

  • Turdimuhammadova Sarvinoz

Keywords:

a-amylase, a-glucosidase, column chromatography, TLC, cardiac glycosides, terpenoids

Abstract

In this study the antidiabetic activity of purified fractions of the endophytic fungus Penicillium brevicaule alba-CC200 isolated from the plant Celosia cristata was investigated Antidiabetic activity was evaluated by inhibition of -amylase enzyme The secondary metabolites of P brevicaule alba-CC200 were partially purified by column chromatography and obtained fraction II inhibited -amylase by 91 2 High inhibitory activity was observed in fraction II and was determined to be cardiac glycosides and terpenoids by thin layer chromatography TLC and qualitative analysis This requires a more precise study of the purified fractions using high-precision chromatographic methods

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How to Cite

Mukhammedov Iqbol, Gulyamova Tashkhan, Ruzieva Dilaram, Nasmetova Saodat, & Turdimuhammadova Sarvinoz. (2023). Study of α-Amylase Inhibitory Activity of Fractions Purified by Chromatographic Methods of the Endophytic Fungus Penicillium Brevicaule Alba-CC200. Global Journal of Medical Research, 23(C2), 15–20. Retrieved from https://medicalresearchjournal.org/index.php/GJMR/article/view/102366

 
Study of α-Amylase Inhibitory Activity of Fractions Purified by Chromatographic Methods of the Endophytic Fungus Penicillium Brevicaule Alba-CC200

Published

2023-06-06

Issue

Vol. 23 No. C2 (2023): GJMR-C Microbiology & Pathology: Volume 23 Issue C2

Section

Articles

License

Copyright (c) 2023 Authors and Global Journals Private Limited

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.