PPIB Unveiled: A Comprehensive Pan-Cancer Exploration Unraveling Immunological Signatures and Prognostic Implications

Abstract

Background Peptidylprolyl isomerase B PPIB has been shown to play an essential role in tumor initiation and progression However it lacks systematic analysis and evaluation of the effect of PPIB on pan-cancer Methods The expression profile and survival analysis of PPIB in tumor tissues were demonstrated by the TIMER2 0 GEPIA2 0 and UALCAN online tools The cBioportal GSCA TISDB and TIMER2 0 databases were applied to analyze the correlation between PPIB and genetic variation immune infiltration and cancer-associated fibroblasts CAFs respectively The STRING GEPIA2 0 and TIMER2 0 databases were used to identify the co-expressed genes of PPIB The DAVID online database was used for GO and KEGG pathway analysis Results PPIB was highly expressed in 20 types of tumors Upregulation of PPIB was associated with a poor prognosis of 6 types of tumors P 0 05 In most cancers the frequency of PPIB genetic variation is relatively low and the common mutation types are missense mutations and splices