Hepatitis C Virus Infected Human Megakaryocytes and Platelets: Intra- and Extracellular Evaluation
DOI:
https://doi.org/10.34257/GJMRCVOL24IS1PG1Keywords:
viral infection, megakaryocytes, platelets, hepatitis C virus, chronic hepatitis C
Abstract
This study aimed to determine whether the hepatitis C virus HCV infects human megakaryocytes and platelets and to measure the expression of receptors involved in virus-cell interaction Platelets from healthy donors were infected with HCV in vitro and analyzed for viral expression and the receptors claudin-1 and cluster of differentiation 81 CD81 HCV was detected on the surface and cytoplasm of both cells cytoplasmic expression was higher compared to the surface Platelets presented a claudin-1 CD81-phenotype and megakaryocytes showed aclaudin-1 CD81 phenotype We conclude that megakaryocytes and platelets are susceptible to HCV infection regardless of CD81 expression and megakaryocytes may serve as possible sites of viral replication
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2024-02-24
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