Entropy and the Lymphatic System, a New Model with Therapeutic Potential

Authors

  • Philip Houck

Keywords:

entropy, lymphatic system, glymphatic function, inflammation, progenitor cells, hs-crp, health model, biological order, regeneration, systems biology

Abstract

A descriptor of life is a phase transition between order and chaos. Entropy is the physical property of this transition determining lifespan. Rules of maintaining entropy and a model of health and disease are presented simplifying scientific methods. Entropy is a term that is poorly understood by physicists and unfamiliar to biologists. Entropy, in a biological context, can be seen as a measure of systemic disorder, with health representing a state of maintained low entropy. The mechanism of maintaining order is the subject of this paper with emphasis on the organ of negative entropy -the lymphatic system.

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How to Cite

Entropy and the Lymphatic System, a New Model with Therapeutic Potential. (2026). Global Journal of Medical Research, 25(B1), 27-38. https://doi.org/10.34257/GJMRBVOL25IS1PG27

References

Peter Macklem, Andrew Seely (2010) Towards a Definition of Life. 53(3), 330-340.

Eleanor Hollywood, Marie Hyland, Muluken Basa (1943) Identifying integrated family support approaches for families living in the International Protection Accommodation Services (IPAS) system in Ireland.

Richard Michod (2007) Evolution of individuality during the transition from unicellular to multicellular life. 104(suppl_1), 8613-8618.

James Valentine (1978) The Evolution of Multicellular Plants and Animals. 239(3), 140-158.

Yan Yan, Julián Hillyer (2020) The immune and circulatory systems are functionally integrated across insect evolution. 6(48), 3164.

C Reiber, I Mcgaw (2009) A review of the "open" and "closed" circulatory systems: new terminology for complex invertebrate circulatory systems in light of current findings. 2009(1), 301284.

A Chipman, G Edgecombe (1912) Developing an integrated understanding of the evolution of arthropod segmentation using fossils and evo-devo. 286, 20191881.

R Rogers, D Hartl (2012) Chimeric genes as a source of rapid evolution in Drosophila melanogaster. 29(2), 517-529.

P Som, M Francois (2017) The Current Concepts of the Embryology of the Lymphatic System. 7(2), 129-150.

M Zhuang, X Zhang, J Cai (2024) Microbiota-gut-brain axis: interplay between microbiota, barrier function and lymphatic system. 16(1), 2387800.

James Mcfadyen, Johannes Zeller, Lawrence Potempa, Geoffrey Pietersz, Steffen Eisenhardt, Karlheinz Peter (2020) C-Reactive Protein and Its Structural Isoforms: An Evolutionary Conserved Marker and Central Player in Inflammatory Diseases and Beyond. 499-520.

Ibraheem Rajab, Peter Hart, Lawrence Potempa (2020) How C-Reactive Protein Structural Isoforms With Distinctive Bioactivities Affect Disease Progression. 11, 2126.

Olde Engberink, R Selvarajah, V Vogt, L (2020) Clinical impact of tissue sodium storage. 35(8), 1373-1380.

Hoon Choi, Hyeong Park, Sung Ha (2015) Salt Sensitivity and Hypertension: A Paradigm Shift from Kidney Malfunction to Vascular Endothelial Dysfunction. 13(1), 7.

T Stougiannou, K Christodoulou, T Koufakis, F Mitropoulos, D Mikroulis, C Mazer, D Karangelis (2024) The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases. 29, 413-436.

Jennaya Christensen, Glenn Yamakawa, Sandy Shultz, Richelle Mychasiuk (2019) Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties. 198(10), 101917.

P Póvoa, L Coelho, J Cidade, A Ceccato, A Morris, J Salluh, V Nobre, S Nseir, I Martin-Loeches, T Lisboa, P Ramirez (2024) Biomarkers in pulmonary infections: a clinical approach. 14(1), 113.

Trisha Singh, Hilal Khan, David Gamble, Caroline Scally, David Newby, Dana Dawson (2022) Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications. 145(13), 1002-1019.

P Houck, H Dandapantula, E Hardegree, J Massey (2020) Why We Fail at Heart Failure: Lymphatic Insufficiency Is Disregarded. 12(6), 8930.

M Braun, J Iliff (2020) The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases. 154, 413-436.

Jennaya Christensen, Glenn Yamakawa, Sandy Shultz, Richelle Mychasiuk (2020) Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties. 198, 101917.

Philip Houck, Hari Dandapantula, Janet Massey (2023) Lymphatics: Future Perspectives Unrealized Potential. 1(2), 87-96.

Nathan Lewis, Jamie Knight (2021) Longitudinal associations between C-reactive protein and cognitive performance in normative cognitive ageing and dementia. 50(6), 2199-2205.

Laura Orsolini, Fabiola Sarchione, Federica Vellante, Michele Fornaro, Ilaria Matarazzo, Giovanni Martinotti, Alessandro Valchera, Marco Di Nicola, Alessandro Carano, Massimo Di Giannantonio, Giampaolo Perna, Luigi Olivieri, Domenico De Berardis (2018) Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of Illness? A Systematic Review. 16(5), 583-606.

T Liukkonen, P Räsänen, J Jokelainen, M Leinonen, M-R Järvelin, V Meyer-Rochow, M Timonen (2011) The association between anxiety and C-reactive protein (CRP) levels: Results from the Northern Finland 1966 Birth Cohort Study. 26(6), 363-369.

M Cepeda, Paul Stang, Rupa Makadia (2016) Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide. 77(12), 1666-1671.

A Macdonald, D Adamis, A Treloar, F Martin (2006) C-reactive protein levels predict the incidence of delirium and recovery from it. 36(2), 222-225.

R Chancel, J Lopez-Castroman, E Baca-Garcia, R Mateos Alvarez, P Courtet, I Conejero (2024) Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review. 26(3), 78-103.

Ye Tu, Yan Fang, Guohui Li, Fei Xiong, Feng Gao (2024) Glymphatic System Dysfunction Underlying Schizophrenia Is Associated With Cognitive Impairment. 50(5), 1223-1231.

S Manti, M Cutrupi, C Cuppari, E Ferro, V Dipasquale, G Di Rosa, R Chimenz, M La Rosa, A Valenti, V Salpietro (2018) Inflammatory biomarkers and intellectual disability in patients with Down syndrome. 62(5), 382-390.

Francisco López-Muñoz, Cecilio Alamo (2009) Historical evolution of the neurotransmission concept. 116(5), 515-533.

Peter Russell, Jiwon Hong, Natalie Trevaskis, John Windsor, Niels Martin, Anthony Phillips (2022) Lymphatic contractile function: a comprehensive review of drug effects and potential clinical application. 118(11), 2437-2457.

Mariappan Muthuchamy, Anatoliy Gashev, Niven Boswell, Nancy Dawson, David Zawieja (2003) Molecular and functional analyses of the contractile apparatus in lymphatic muscle. 17(8), 1-25.

Joshua Scallan, Scott Zawieja, Jorge Castorena‐gonzalez, Michael Davis (2016) Lymphatic pumping: mechanics, mechanisms and malfunction. 594(20), 5749-5768.

Ron Sender, Ron Milo (2021) The distribution of cellular turnover in the human body. 27(1), 45-48.

Anatoliy Gashev, David Zawieja (2010) Hydrodynamic regulation of lymphatic transport and the impact of aging. 17(4), 277-287.

Philip Houck (2025) The Era of Risk Factors Should End; the Era of Biologic Age Should Begin. 6(1), 2.

Philip Houck, Jose De Oliveira (2013) Applying laws of biology to diabetes with emphasis on metabolic syndrome. 80(5), 637-642.

William Kraus, Kenneth Powell, William Haskell, Kathleen Janz, Wayne Campbell, John Jakicic, Richard Troiano, Kyle Sprow, Andrea Torres, Katrina Piercy (2018) Physical Activity, All-Cause and Cardiovascular Mortality, and Cardiovascular Disease. 51(6), 1270-1281.

Roger Chou, T Dana, I Blazina, M Daeges, T Jeanne (2016) Error in USPSTF Report on Statin Use. 323(7), 669.

Chang Geng, Yu-Cheng Mao, Su-Fen Qi, Kai Song, Hong-Fei Wang, Zi-Yan Zhang, Qing-Bao Tian (2023) Mineralocorticoid receptor antagonists for chronic heart failure: a meta-analysis focusing on the number needed to treat. 10, 1236008.

Shelley Salpeter, Judith Walsh, Elizabeth Greyber, Thomas Ormiston, Edwin Salpeter (2004) Mortality associated with hormone replacement therapy in younger and older women. 19(7), 791-804.

Edmond Li, Balraj Heran, James Wright (2014) Angiotensin converting enzyme (ACE) inhibitors versus angiotensin receptor blockers for primary hypertension. 2014(8), 0-9096.

Henrik Svanström, George Mkoma, Anders Hviid, Björn Pasternak (2024) SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction: linked database study. 387, e080925.

Søren Kristensen, Rasmus Rørth, Pardeep Jhund, Kieran Docherty, Naveed Sattar, David Preiss, Lars Køber, Mark Petrie, John Mcmurray (2019) Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. 7(10), 776-785.

S Kritchevsky, K Beavers, M Miller, M Shea, D Houston, D Kitzman, B Nicklas (2015) Intentional weight loss and all-cause mortality: a meta-analysis of randomized clinical trials. 10(3), 121993.

Ibadete Bytyçi, Gani Bajraktari, Peter Penson, Michael Henein, Maciej Banach (2022) Efficacy and safety of colchicine in patients with coronary artery disease: A systematic review and meta‐analysis of randomized controlled trials. 88(4), 1520-1528.

George Sokos, Amresh Raina (2020)

Understanding the early mortality benefit observed in the PARADIGM-HF trial: considerations for the management of heart failure with sacubitril/valsartan

. Volume 16, 41-51.

P Ridker, P Libby, J Macfadyen, T Thuren, C Ballantyne, F Fonseca, W Koenig, H Shimokawa, B Everett, R Glynn (2018) Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). 39(38), 3499-3507.

V Kytö, A Tornio (2024) Ezetimibe use and mortality after myocardial infarction: A nationwide cohort study. 19, 100702.

P Kidd (2003) Th1/Th2 Balance. 8(3), 223-246.

P Houck (2014) Should negative entropy be included in the fundamental laws of biology?. 2(1), 7.

Philip Houck (2020) Making Drug Discovery More Efficient Applying Statistical Entropy to Biology. 11(12), 1969-1976.

Wolfram A New Kind of Science.

Entropy and the Lymphatic System, a New Model with Therapeutic Potential

Published

2026-01-07

How to Cite

Entropy and the Lymphatic System, a New Model with Therapeutic Potential. (2026). Global Journal of Medical Research, 25(B1), 27-38. https://doi.org/10.34257/GJMRBVOL25IS1PG27