Ebola Virus Disease in sub-Saharan Africa: History, Contemporary Epidemiology and Recommendations
Keywords:
ebola virus, ebola virus disease, sub-saharan africa, case fatality ratio, epidemic, outbreak
Abstract
Between 2017 and 7 March 2025, Ebola virus disease occasioned eight outbreaks killing 2,471 people out of 3,892 cases in sub-Saharan Africa. Given the pandemic capacities of the largest Ebola epidemics that occurred in West Africa from 2014-2016 and the socioeconomic catastrophe wrought by the COVID-19 pandemic, all hands must be on deck to mitigate recurrent Ebola outbreaks. Hence, this piece explores the historical trajectory of Ebola virus disease and its epidemiological attributes in the contemporary era. We deployed a narrative review of relevant articles on the Ebola virus disease from its inception in 1976 to 2025. Between 2001 and 2025, 26 outbreaks of EVD occurred in sub-Saharan Africa, with an average case fatality rate of 43 percent. We discovered that 46 percent of the epidemics occurred in DRC Congo, and Zaire Ebola strains were responsible for 73 percent of outbreaks.
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References
Samantha Anderer (2025) Sudan Virus Disease Outbreak in Uganda Spurs First-Ever Ebola Vaccine Trial. 333(14), 1195.
Cdc (2024) Ebola Outbreak History.
A Nanbo, S Watanabe, P Halfmann, Y Kawaoka (2013) The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells. 3, 1206.
A Kadanali, G Karagoz (2015) An Overview of Ebola Virus Disease. 2(1), 81-86.
Suresh Rewar, Dashrath Mirdha (2014) Transmission of Ebola Virus Disease: An Overview. 80(6), 444.
M Broadhurst, Tim Brooks, Nira Pollock (2016) Diagnosis of Ebola Virus Disease: Past, Present, and Future. 29(4), 773-793.
B Zawilińska, M Kosz-Vnenchak (2014) General introduction into the Ebola virus biology and disease. 54(3), 57-65.
Pierre Nouvellet, Tini Garske, Harriet Mills, Gemma Nedjati-Gilani, Wes Hinsley, Isobel Blake, Maria Van Kerkhove, Anne Cori, Ilaria Dorigatti, Thibaut Jombart, Steven Riley, Christophe Fraser, Christl Donnelly, Neil Ferguson (2015) The role of rapid diagnostics in managing Ebola epidemics. 528(7580), S109-S116.
A Leligdowicz, Fischer Wa 2nd, T Uyeki (2016) Ebola virus disease and critical illness. 20, 217.
T West, Von Saint André-Von Arnim, A (2014) Clinical presentation and management of severe Ebola virus disease. 11, 1341-1350.
Luke Hunt, Ankur Gupta-Wright, Victoria Simms, Fayia Tamba, Victoria Knott, Kongoneh Tamba, Saidu Heisenberg-Mansaray, Emmanuel Tamba, Alpha Sheriff, Sulaiman Conteh, Tom Smith, Shelagh Tobin, Tim Brooks, Catherine Houlihan, Rachael Cummings, Tom Fletcher (2015) Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study. 15(11), 1292-1299.
Denis Malvy, Anita Mcelroy, Hilde De Clerck, Stephan Günther, Johan Van Griensven (2019) Ebola virus disease. 393(10174), 936-948.
Pierre-Stéphane Gsell, Anton Camacho, Adam Kucharski, Conall Watson, Aminata Bagayoko, Séverine Nadlaou, Natalie Dean, Abdourahamane Diallo, Abdourahmane Diallo, Djidonou Honora, Moussa Doumbia, Godwin Enwere, Elizabeth Higgs, Thomas Mauget, Diakite Mory, Ximena Riveros, Fofana Oumar, Mosoka Fallah, Alhassane Toure, Andrea Vicari, Ira Longini, W Edmunds, Ana Henao-Restrepo, Marie Kieny, Sakoba Kéïta (2017) Ring vaccination with rVSV-ZEBOV under expanded access in response to an outbreak of Ebola virus disease in Guinea, 2016: an operational and vaccine safety report. 17(12), 1276-1284.
(2023) World Health Organization expedites trials for potential Ebola vaccines.
S Okware, F Omaswa, A Talisuna, J Amandua, J Amone, P Onek, A Opio, J Wamala, J Lubwama, L Luswa, P Kagwa, T Tylleskar (2015) Managing Ebola from rural to urban slum settings: experiences from Uganda. 15(1), 312.
G Caleo, J Duncombe, F Jephcott (2018) The factors affecting household transmission dynamics and community compliance with Ebola control measures: a mixed-methods study in a rural village in Sierra Leone. 18, 248.
T Shoemaker, S Balinandi, A Tumusiime (2018) Impact of enhanced viral haemorrhagic fever surveillance on outbreak detection and response in Uganda. 18, 373-375.
S Funk, I Ciglenecki, Tiffany (2017) The impact of control strategies and behavioural changes on the elimination of Ebola from Lofa County, Liberia. 372, 20160302.
J Izudi, F Bajunirwe (2024) Case fatality rate for Ebola disease, 1976-2022: A meta-analysis of global data. 17, 25-34.
Derek Taylor, Robert Leach, Jeremy Bruenn (2010) Filoviruses are ancient and integrated into mammalian genomes. 10(1), 193.
Y Suzuki, T Gojobori (1997) The origin and evolution of Ebola and Marburg viruses. 14(8), 800-806.
M Balter (2000) Emerging diseases. On the trail of Ebola and Marburg viruses. 290, 923-925.
Michael Murray (2015) Ebola Virus Disease. 121(3), 798-809.
(1978) Tough challenges for testing Ebola therapeutics. 93(2), 70-71.
T Muyembe, M Kipasa (1978) Ebola haemorrhagic fever in Kikwit, Zaire. 345(8962), 1448.
P Jahrling, T Geisbert, E Johnson, C Peters, D Dalgard, W Hall (1990) Preliminary report: isolation of Ebola virus from monkeys imported to USA. 335(8688), 502-505.
R Barrette, S Metwally, J Rowland, L Xu, S Zaki, Nichol St (2009) Discovery of swine as a host for the Reston ebolavirus. 325, 204-206.
L Schnirring (2025) Second Cluster recorded in Uganda's Ebola Sudan Outbreak.
O Kavulikirwa, F Sikakulya (2022) Recurrent Ebola outbreaks in the eastern Democratic Republic of the Congo: A wake-up call to scale up the integrated disease surveillance and response strategy. 14, 100379.
Augustine Avwunudiogba, Elisha Dung (2021) The Spatial Distribution of Internally Displaced Persons (IDPs) in Africa. 17-43.
Prince Muzuva, Aaram Gwiza, Vain Db Jarbandhan (2025) "Kagametizing" the DRC conflict: Dissecting historical connotations and influence of the invisible hands. 14(3), 59-76.
S Languon, O Quaye (2019) Filovirus Disease Outbreaks: A Chronological Overview.
Hui-Ju Han, Hong-Ling Wen, Chuan-Min Zhou, Fang-Fang Chen, Li-Mei Luo, Jian-Wei Liu, Xue-Jie Yu (2015) Bats as reservoirs of severe emerging infectious diseases. 205, 1-6.
T Kamorudeen, K Adedokun, A Olarinmoye (2020) Ebola outbreak in West Africa, 2014 -2016: Epidemic timeline, differential diagnoses, determining factors, and lessons for future response. 13(7), 956-962.
J Kuhn, G Amarasinghe, D Perry (2020) Fields Virology: Emerging Viruses 7th edn Ch. 12.
(2020) Figure 1: Dynamics of Ebola virus disease (EVD) outbreak in the Democratic Republic of Congo (DRC)..
Ishani Chakrabartty, Maryam Khan, Saurov Mahanta, Hitesh Chopra, Manish Dhawan, Om Choudhary, Shabana Bibi, Yugal Mohanta, Talha Emran (2022) Comparative overview of emerging RNA viruses: Epidemiology, pathogenesis, diagnosis and current treatment. 79, 103985.
Laura Baseler, Daniel Chertow, Karl Johnson, Heinz Feldmann, David Morens (2017) The Pathogenesis of Ebola Virus Disease. 12(1), 387-418.
L Koch, S Cunze, J Kochmann (2020) Bats as putative Zaire ebolavirus reservoir hosts and their habitat suitability in Africa. 10, 14268.
Aurora Bettini, Daniele Lapa, Anna Garbuglia (2023) Diagnostics of Ebola virus. 11, 1123024.
Antoine Nkuba-Ndaye, Angele Dilu-Keti, Tamara Tovar-Sanchez, Mamadou Diallo, Daniel Mukadi-Bamuleka, Richard Kitenge, Pierre Formenty, Anaïs Legand, François Edidi-Atani, Guillaume Thaurignac, Raphael Pelloquin, Placide Mbala-Kingebeni, Abdoulaye Toure, Ahidjo Ayouba, Jean-Jacques Muyembe-Tamfum, Eric Delaporte, Martine Peeters, Steve Ahuka-Mundeke, Steve Ahuka-Mundeke, Nella Bisento-Ngafa, Junior Bulabula-Penge, Bernice Danga-Yema, François Eddi-Atani, Eddy Kinganda-Lusamaki, Antoine Nkuba-Ndaye, Fabrice Mambu Mbika, Gabriel Kabamba Lungenyi, Meris Matondo Kiamfumu, Placide Mbala-Kingebeni, Daniel Mukadi-Bamuleka, Jean-Jacques Muyembe-Tamfum, Eric Delaporte, Ahidjo Ayouba, Julie Boullin, Angèle Dilu-Keti, Audrey Lacroix, Martine Peeters, Raphael Pelloquin, Guillaume Thaurignac, Tamara Tovar Sanchez, Richard Kitenge, Pierre Formenty, Anaïs Legand, Eric Panzi-Kalunda, Callixte Kakule-Sadiki, Guillaume Kambale-Kasyamboko, Nelson Kambale-Sivihwa, Sheila Kavira-Muhesi, Eli Kavoyo-Mbayayi, Divine Kitsa-Mutsumbirwa, Fyfy Mbelu-Matulu, Noella Mulopo-Mukanya, Elias Mumbere-Kalemekwa, Defao, Grace Paluku-Salambongo, Ekoko, Abdoulaye Touré, Mamadou Diallo (2024) Effect of anti-Ebola virus monoclonal antibodies on endogenous antibody production in survivors of Ebola virus disease in the Democratic Republic of the Congo: an observational cohort study. 24(3), 266-274.
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2026-01-09
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