Building a Global Central Database for Promising Herbal Antimalarials from Various Countries: Strategies for Safe and Effective Drug Development

Authors

  • Dr. Omagha Rachel

  • Dr. Esther O. Agbaje

  • Dr. Chibuisi G. Alimba

  • Dr. Ajaegbu C.N. Henry

Keywords:

global collaboration, central database, antimalarial-herbs and drugs, high-throughput and multi-omics screening, patients safety

Abstract

Drug databases have become a critical tool used by various stakeholders to make informed decisions about medication therapy. Globally, researchers have carried out primary studies that have documented and provided knowledge on the antiplasmodial activities of numerous plants. A central database designed to document vital efficacy and safety information on the most promising antimalarial-medicinal plants being recommended for advanced studies in the drug discovery and development pipeline is needed to serve as vital repository supporting the general public, researchers, academic institutions, pharmacological companies, policymakers, and patients relying on herbal antimalarials. Current malaria research programs require the use of advanced techniques in the development of new antimalarials.

Downloads

How to Cite

Building a Global Central Database for Promising Herbal Antimalarials from Various Countries: Strategies for Safe and Effective Drug Development. (2026). Global Journal of Medical Research, 25(B1), 39-44. https://doi.org/10.34257/GJMRBVOL25IS1PG39

References

(2017) Explore key features of the most comprehensive database of its kind.

(2017) Drugs, herbs.

Memorial Sloan, -Kettering Cancer Center (2017) About herbs, botanicals & other products.

Aracil Amparo, Julia Green (2019) Plants with antimalarial properties: A systematic review of the current clinical evidence. 28, 76-85.

Rachel Omagha, Emmanuel Idowu, Chibuisi Alimba, Adetoro Otubanjo, Adeniyi Adeneye (2021) Survey of ethnobotanical cocktails commonly used in the treatment of malaria in southwestern Nigeria. 7(1), 152.

Onk Martey, O Shittah-Bay, J Owusu, Lkn Okine (2013) The antiplasmodial activity of an herbal antimalarial, AM 207 in Plasmodium bergheiinfected Balb/c Mice: absence of organ specific toxicity. 13(7), 537-545.

(2024) Addressing inequity in the global malaria response.

Xi Zhou, Yongquan Li, Xin Chen (2010) Computational identification of bioactive natural products by structure activity relationship. 29(1), 38-45.

T Belete (2020) Recent Progress in the Development of New Antimalarial Drugs with Novel Targets (2020). 14, 3875-3889.

R Omagha, E Idowu, C Alimba, A Otubanjo, E Agbaje, Hcn Ajaegbu (1948) Physicochemical and phytochemical screening of six plants commonly used in the treatment of malaria in Nigeria.. 19(2), 483-501.

R Omagha, E Idowu, C Alimba, A Otubanjo, W Oyibo, E Agbaje (2021) In vivo antiplasmodial activities and acute toxicity assessment of two plant cocktail extracts commonly used among Southwestern Nigerians.

Rachel Omagha, Emmanuel T Idowu, Chibuisi G Alimba, Adetoro O Otubanjo, Esther O Agbaje, Wellington A Oyibo (1948) Clinico-biochemical and histopathological alterations in sub-chronically exposed mice (Mus Musculus) to polyherbal antimalarials. 17(40), 1-30.

Rachel Omagha, Emmanuel T Idowu, Chibuisi G Alimba, Adetoro O Otubanjo, Esther O Agbaje, Wellington A Oyibo (1947) Alterations in testis histology, reproductive hormones and abnormal sperm morphology in mice treated with polyherbal antimalarials. 17(40), 1-12.

F-C Czygan (2019) The role of medicinal plants as an important part in modern medicine (2019). AdvHorticSci 1990:56-60. A brief review of traditional plants as sources of pharmacological interests. 4, 1-8.

M Ocan, Loyce Ojiambo, K (2023) Efficacy of antimalarial herbal medicines used by communities in malaria affected regions globally: a protocol for systematic review and evidence and gap map. 13, 69771.

S Wachtel-Galor, I Benzie (2011) Herbal medicine: an introduction to its history, usage, regulation, current trends, and research needs IFF.

(2011) Herbal Medicine: Biomolecular and Clinical Aspects.

Timothy Wells, Rob Van Huijsduijnen (2015) Ferroquine: welcome to the next generation of antimalarials. 15(12), 1365-1366.

Monica Noronha, Vishakha Pawar, Anil Prajapati, R Subramanian (2020) A literature review on traditional herbal medicines for malaria. 128, 292-303.

M Frenkel, E Arye (2001) The growing need to teach about complementary and alternative medicine: questions and challenges. 76(3), 251-254.

Osvaldo Almeida (2003) Atlas: Mental Health Resources in the World 2001. Edited by S. Saxena. (Pp. 55; available free from WHO, CH1211 Geneva 27, Switzerland.) World Health Organization: Geneva. 2001.. 33(3), 563-568.

A Moronkeji, G Eze, M Igunbor, A Ogbonna, A Moronkeji (2019) Histomorphological and biochemical evaluation of herbal cocktail used in treating malaria on kidneys of adult wistar rats. 3(7), 57-66.

C Orabueze, A Sunday, O Duncan, C Herbert (2018) In vivoantiplasmodial activities of four Nigerian plants used singly and in polyherbal combination against Plasmodium berghei infection.

O Martey, O Shittah-Ba, J Owusu, L Okine (2013) The Antiplasmodial Activity of an Herbal Antimalarial, AM 207 in Plasmodium berghei-infected Balb/c Mice: Absence of Organ Specific Toxicity. 13(7), 537-545.

I Rusyn, G Daston (2010) Computational toxicology: realizing the promise of the toxicity testing in the 21st century. 118(8), 1047-1050.

E David, T Tramontin, R Zemmel (2009) Pharmaceutical R&D: the road to positive returns.

Jürgen Drews, Stefan Ryser (1997) Drug Development: The role of innovation in drug development. 15(13), 1318-1319.

J Davies, D Davies (2010) Origins and evolution of antibiotic resistance. 74(3), 417-433.

Lance O'connor, Blake O'connor, Su Lim, Jialiu Zeng, Chih Lo (2023) Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective. 13(8), 836-850.

N Siddharthan, M Raja Prabu, B Sivasankari (2016) Bioinformatics in Drug Discovery a Revi. 2(2), 11-13.

S Shaikh, B Jayaram (2007) A Swift All-Atom Energy-Based Computational Protocol to Predict DNA-Ligand Binding Affinity and Δ T m. 50(9), 2240-2244.

Rasmus Petersen, Kathrine Christensen, Andreana Assimopoulou, Xavier Fretté, Vassilios Papageorgiou, Karsten Kristiansen, Irene Kouskoumvekaki (2011) Pharmacophore-driven identification of PPARγ agonists from natural sources. 25(2), 107-116.

P Whittaker (2003) What is the relevance of bioinformatics to pharmacology?. 24(8), 434-439.

Y Chen, F Chen (2008) Identifying targets for drug discovery using bioinformatics. 12, 383-389.

F Mojab (2012) Antimalarial natural products: a review. 2(2), 52-62.

M Fowler (2006) Plants, medicines and man. 86(12), 1797-1804.

A Dawet, D Yakubu, R Omagha, J Gushit (2023) Isolation of the active ingredients of antimalarial activity of the stem bark of Pseudocedrelakotschyi (Dry zone cedar). 44(1).

C Wu, J Chen, Lai-Han Leung, E, Chang, Wang (2022) Editorial: Artificial Intelligence in Traditional Medicine. 13, 933133.

Zeeshan Afsar, R Nethaji, K Vimal, K Shantiya, M Manjunatha, Rajendra Prasad, M, Babu Ganesan (2025) Modern Concepts of Integrating Artificial Intelligence with Traditional and Herbal Medicine: A Review. 2(2), 43-49.

Building a Global Central Database for Promising Herbal Antimalarials from Various Countries: Strategies for Safe and Effective Drug Development

Published

2026-01-07

How to Cite

Building a Global Central Database for Promising Herbal Antimalarials from Various Countries: Strategies for Safe and Effective Drug Development. (2026). Global Journal of Medical Research, 25(B1), 39-44. https://doi.org/10.34257/GJMRBVOL25IS1PG39