In-silico Analysis – Phytochemicals against ‘mGluR5’ for Therapeutic Intenvention in the Intellect, in Fragile X Syndrome

Abstract

Intellectually different ability or intellectual disability (ID)’ exhibits neurodevelopmental deficits, which manifests as limitations in ‘intellectual functioning’ and ‘adaptive behavior’. ‘Fragile X syndrome’ is the common genetic cause of ID. Therefore in this in-silico research, the protein ‘mGluR5’ was targeted for the therapy of ID, in Fragile X Syndrome. In Fragile X syndrome, due to mutation in FMR1 gene, there’s lack of FMRP (Fragile X Mental Retardation Protein), resulting in unimpeded activity of ‘mGluR5’, which leads to aberrant dendritic development with mis-signalling. This results in ID, autism and psychopathology. An attempt towards overcoming this problem of ID, in Fragile X syndrome, in this research, ‘mGluR5’ was targeted against 19 different phytochemicals, collected from IMPPAT 2.0 database. 3D-structure of ‘mGluR5’ was obtained from RCSB-PDB, then the phytochemicals were docked against ‘mGluR5’ using CB-Dock.