Study of Weekly Paclitaxel with Concurrent Radiotherapy V/S Weekly Cisplatin with Concurrent Radiotherapy in Advanced Cervix Carcinoma
Abstract
Purpose: To evaluate the Response and Efficacy of weekly paclitaxel with concurrent radiotherapy in comparison to weekly cislatin with concurrent radiotherapy in advanced cervical cancer patients. Methods: Patients coming to the department of radiotherapy S.M.S Hospital were included in the study.50 patients of advanced squamous cell carcinoma of cervix FIGO stage III &IV were selected. In the study and control group , patients were given 5 weeks of external beam radiotherapy followed by brachytherapy. External beam irradiation each of 200cGy/fr, on linear acceleretor by parallel opposed - anterior and posterior fields was given. External beam irradiation was followed by Intracavitary brachytherapy 700cGy/week for 3 weeks each with High Dose Rate Iridium 192 source. Patients received 50 Gy by External beam irradiation (200cGy/fr, total 25 Fr) and 21 Gy by Intracavitary brachytherapy (7Gy/fr, 3fr) .In control group, patients were treated by concurrent weekly cisplatin with external beam radiotherapy.In study group patients were treated by concurrent weekly paclitaxel with external beam radiotherapy. Results: At end of the completion of treatment 76% in the study group and 72% in the control group were found to have complete response to the treatment, 16% and 20% were found to have partial response in the study and control group respectively.statistical analysis was done by chi Square test. After 6 months of completing the treatment the result were equivalent in both the groups, 84% had complete response and 8% had partial response. Though the difference in tumour response was not statistically significant(χ2 = .13, p = 0..94)., the rate of reduction in tumor size was found faster in study group at the end of the treatment, complete response was little more in the study group. The vomiting during the treatment is statistically significantly more in the control group( χ2=23.548,p=
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2013-12-04
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