Characterization of Hippocampus in Epileptic Sudanese Children using MRI
Keywords:
epilepsy, hippocampus, siezers
Abstract
Seizures are the most noticeable clinical manifestations of epilepsy; measurement of the hippocampus on magnetic resonance (MR) images of the brain has been useful for the assessment of patients with seizures. Therefore this study aimed to diagnose subjects who had developed epilepsy by measuring the RT and LT hippocampus area and volume considering epilepsy duration, seizure frequency, EEG results, T2 signal intensity, treatment, and children ages as well as to correlate the MRI findings with EEG findings. This Study was conducted at Gezira University- MRI Diagnostic center -Khartoum -Sudan during the period from 2010up to2011using Siemens 0.5 Tesla MRI machine. A total of 29 Sudanese children of both genders with clinical history of generalized seizures, and 17 normal children who were selected as control group at different ages were involved in this study. Children with head injury or organic lesion found on MR images were excluded. The hippocampus was characterized in the coronal MR images; the area and volume of the right and Left sides were found to be reduces significantly in the diseased sample comparing with the control group; there was relationship between patient's age and seizure duration and frequency as well as hippocampus area and volume. Significant differences were detected in the hippocampus area and volume in children who have got treatment and none treated children.T2 weighted images showed hyper signal intensity in the hippocampuses of the diseased sample. No significant differences were detected in males and females measurements. EEG failed in diagnoses of 12 (41.4%) cases of the sample, and new formulas were established for prediction of EEG findings regarding the hippocampus area and epilepsy duration.MRI has a great value in characterization hippocampus in epileptic Sudanese children.
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2013-12-04
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