High-Flow Priapism Following Chlorpromazine Induced Low- Flow Priapism

Mohamed Saad Hegazy; Mustafa MR

Authors

Mohamed Saad Hegazy
Mustafa MR

Keywords:

Abstract

Priapism is defined as a penile erection that persists more 4 hours or longer and is unrelated to sexual activity. The three main subtypes are low flow (ischemic), high flow (nonischemic) and stuttering (intermittent or recurrent) priapism. Alpha-1 antagonistic activities of some antipsychotics, especially chlorpromazine, have been reported to be responsible for development of low-flow priapism. Chlorpromazine has the greatest alpha-adrenergic affinity among the conventional antipsychotic agents and the most frequently reported to be associated with priapism. We report a case of priapism after a first single dose of chlorpromazine (Neurazine ® 100 mg tablet, Misr Co. For Phramind-Egypt). The case was presented first by neglected lowflow priapism that had been converted to high-flow priapism due to injury of a branch of the cavernosal artery, during aspiration and irrigation treatment procedure, proved by blood gas testing of the aspirated penile blood, penile color duplex Doppler ultrasonography and selective left internal pudendal arteriogram. This conversion is an uncommon complication of such procedure.

Downloads

How to Cite

High-Flow Priapism Following Chlorpromazine Induced Low- Flow Priapism. (2018). Global Journal of Medical Research, 18(K5), 17-24. https://medicalresearchjournal.org/index.php/GJMR/article/view/1569

Download Citation

References

J Halls, D Patel, M Walkden, U Patel (2012) Priapism: pathophysiology and the role of the radiologist. 85(special_issue_1), S79-S85.

Muharrem Baytunca, Sezen Kose, Burcu Ozbaran, Serpil Erermis (2016) Risperidone, quetiapine and chlorpromazine may have induced priapism in an adolescent. 58(1), 61-63.

A Muneer, D Ralph (2017) Guideline of guidelines: priapism. 119(2), 204-208.

Andrea Salonia, Ian Eardley, François Giuliano, Dimitrios Hatzichristou, Ignacio Moncada, Yoram Vardi, Eric Wespes, Konstantinos Hatzimouratidis (2014) European Association of Urology Guidelines on Priapism. 65(2), 480-489.

C Wallis, N Hoag, P Pommerville, M Huk (2009) Recurrent idiopathic high-flow priapism treated with selective arterial embolization after repeated initial treatments for low-flow priapism. 3(1), 60-63.

M Habous, M Elkhouly, O Abdelwahab (2016) Noninvasive treatments for iatrogenic priapism: Do they really work? A prospective multicenter study. 8(2), 193-196.

M Shahrbabaki, L Sabzevari (2011) Early onset priapism under chlorpromazine and risperidone therapy. 5(2), 139-142.

S Turkan, M Kalkan, C Şahin (2014) Two Priapism Cases Following Short-Term Use of Chlorpromazine. 05(Suppl_1), 47-48.

Mete Kilciler, Selahattin Bedir, Fahri Sümer, Murat Dayanç, Ahmet Peker (2003) Priapism in a Patient Receiving Long-Term Chlorpromazine Therapy. 71(1), 127-128.

Frank Andersohn, Niklas Schmedt, Stefan Weinmann, Stefan Willich, Edeltraut Garbe (2010) Priapism Associated With Antipsychotics. 30(1), 68-71.

I Marrag, R Soussia, Ben, K Hajji, L Zarrouk, Y Binous, M Nasr (2016) Priapisme induit par la chlorpromazine: A propos de deux cas. 22(2), 131-135.

Austin Lutz, Stephen Lacour, Wayne Hellstrom (2012) Conversion of Low‐Flow to High‐Flow Priapism: A Case Report and Review (CME). 9(4), 951-954.

C Mcmahon (2002) High flow priapism due to an arterial-lacunar fistula complicating initial veno-occlusive priapism. 14(3), 195-196.

J Park, Y Jeong, Y Han, H Kim (2003) High‐flow priapism caused by injury of the bilateral cavernosal artery after needle trauma in a patient with low‐flow priapism. 92(s3), 1-2.