Chitraka Haritaki Avaleha is a Leha Kalpana (semisolid preparation of drugs, prepared with addition of jaggery & boiled with prescribed decoction) specifically indicated for oral use in treatment of nasal disorders in Ayurveda. Shikhari Taila is a formulated oil with the herbs having medicinal values. Use of Shikhari Taila for Nasya (one of the Panchakarma procedure mentioned in Ayurveda) in Nasa Arsha (Nasal polyposis) has been mentioned in Ayurvedic texts, but no work has been done at any of the PG centers of Ayurvedic Institutes. Both the drugs are having anti histaminic & anti inflammatory properties. Hence the present study was designed to ascertain whether it is possible to obtain experimental data to support the clinical study; and helps to prove the above theory, according to criteria of modern pharmacology too.