Abstract

Hepatic fat and abdominal adiposity in early pregnancy promotes impaired glucose homeostasis in mid-pregnancy De Souza 2016 and paracetamol overuse predisposes to liver fat Hyperglycemia induces apoptosis in myocardium and an amount evidence have demonstrated an increased risk of congenital abnormalities with gestational diabetes Acetaminophen overdose is the most often cause of acute liver injury and obese women are in particular risk because is able to induce mitochondrial oxidative stress Rousar 2012 Acetaminophen Paracetamol usual high doses decreased embryonic hepatic antioxidant systems as glutathione that play a vital role in the detoxification of exogenous and endogenous chemicals Mitchell 1973 Ishibashi 1997 Beck 2001 Rousar 2012 rev The apparent safety of Paracetamol drug a useful analgesic only with no anti-inflammatory properties Neto 2004 Hamlyn 1978 Ucheya 2006 Bessems 2001 is compromized by its widespread and extensive chronic use particularly in Peruvian population Paracetamol though considered safe at a considerable low dose especially in women could cause kidney derangement and cardiac malformations during pregnant state Ucheya 2006 if the drug is ingested in the first trimester Major congenital malformations including those affecting the cardiovascular system remain the leading cause of mortality and morbidity in infants of diabetic mothers Pinter 2001 Thus there is an overcome potential maternal acetaminophen paracetamol toxicity Horowitz 1997