Aim: To establishing the use of Quercetin as a nutraceutical potential against Coronavirus Disease 2019. Method: This study is a descriptive, prospective longitudinal that included 52 patients treated at the ECOMED-LAMB Clinic from the onset of Covid-19 in our country, March 3, 2020, to January 2021. Result s: Were studied 52 patients COVID-19 positive, 20 (38.4%) were in preventive treatment, and 32 patients (61.5%) biological therapy were administered once the diagnosis; no difference was found between female or male sex and the predominant age was those over 60 years. Twenty-four patients (70.6%) have presented at least one comorbidity. The association of hospitalization with preventive treatment was not significant (p=0.166); we observed a difference during the hospital stay of the patients (p= 0.084). Conclusions: Quercetin could prevent and decrease the duration of SARS-CoV-2 infections, it is plausible to propose the prophylactic use of this flavonoid to achieve clinical benefits.