Abstract

Purpose While there is now considered to be no significant outcome impact of the timing of breast surgery in the menstrual cycle of premenopausal women with breast cancer the data with respect to adjuvant surgical oophorectomy in women with breast cancer have received limited exposition and attention In a trial investigating the timing of surgical oophorectomy in women with metastatic disease we observed a trend for poorer overall survival in women in women in prolonged follicular phases of the menstrual cycle with low progesterone levels Methods The data from a previously reported adjuvant randomized clinical trial addressing the timing of surgical oophorectomy in the menstrual cycle have been examined in detail presenting here new data from pre-planned secondary analyses Multivariable Cox models were used