Gallbladder stones in children are one complication, most seen in such diseases as hemolytic disease, liver disease, and obesity. They can be a secondary complication of long duration used of antibiotics like ceftriaxone. However, Gallbladder stone and together with sludge themselves is unusual within the children population. We were observed in some instances by a particular sort of antibiotic that is being referred by Ceftriaxone. It is the third-generation cephalosporin with a wide broad-spectrum utilized in treating multiple complicated infected organisms. Here, in this study, we report three cases of children with age degrees from eleven months to seven years who have been treated with high doses and long duration of ceftriaxone for complicated systemic bacterial infection. The purpose of this study was to determine the dose and duration of ceftriaxone in children who developed gallbladder stones after treating complex bacteria with ceftriaxone and to evaluate the outcome of the treatment in these patients.