Organophosphate compounds have been a common source of mortality in recent times. A typical example is dichlorvos [2, 2-Dichlorovinyldimethylphosphate (DDVP)]; an important agricultural pesticide. This study sought to investigate the phytochemical screening, in-vitro antioxidant property of the leaf solvents extracts and ameliorating effects of Senna siameain DDVP-induced brain oxidative stress in Wistar rats. The aqueous, methanol and ethanol extracts of the leaves were obtained and analyzed for their in-vitro antioxidant parameters. Thirty-two healthy Wistar albino rats were grouped into eight of 4rats each weighing between 140-150g. The animals were orally administered with 6.6mg/kg body weight of DDVP except groups1 and 2 followed by treatments with the three solvents extracts respectively that lasted for four weeks.

How to Cite
OLAIYA PETER, OSENI, OLATUNDE ABASS, OKOH, OLAYINKA SUNDAY, Oni,. The Impact of Senna Siamea (Lam) leaves extracts on 2, 2-Dichlorovinyldimethyl Phosphate Induced Brain Oxidative Stress in Wistar Albino Rats. Global Journal of Medical Research, [S.l.], oct. 2021. ISSN 2249-4618. Available at: <https://medicalresearchjournal.org/index.php/GJMR/article/view/2552>. Date accessed: 06 july 2022.

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