Background: Overuse of both methylprednisolone and dexamethasone drug on a corona patient can result in serious side effects and new infections may appear during their use. Infection with any pathogen, including viral, bacterial, fungal, protozoan, or helminthic infections at any site of the body, may be associated with the use of methylprednisolone or dexamethasolone in combination with other immunosuppressive agents that increase cellular immunity, humoral immunity, or Suppress neutrophils. The function they affect. These infections can be mild, but can be serious and sometimes fatal. With increasing doses of methylprednisolone and dexamethasone, the rate of occurrence of infectious complications increases. When methylprednisolone and dexamethasone are used, there may be reduced resistance and inability to localize the infection.