West Africa is reputed as an epicenter of HIV-2 infection. Studies undertaken in Mali suspected HIV-1 more prevalent. Our study aims to document HIV infectious profiles in Mali and analyze HIV-1 dominance. We documented HIV studies undertaken in Mali from 1985 to 2010. We proceeded to a bibliographic search focused on theses from the Medicine Pharmacy Odontostomatology Faculty (FMPOS) of Bamako, survey reports, and abstracts or papers published in reviews with the reading committee. Documents were physically and virtually (via website) consulted and exploited. We gave preference to studies that discriminated against HIV serotypes. The data were analyzed according to study population/publication, representativeness, infectious profiles reporting, socio-demographic and clinical characteristics. HIV profiles variation in space and time was analyzed by using a linear regression model. Calculations were done using Excel software.