The incidence and demographic data of cancer is the important basis for cancer prevention. Lip, oral cavity and pharyngeal cancers (LOCP) have a variety of geographic distribution and multiple risk factors. This study aims to describe and compare the epidemiological profile of LOCP cancers. A retrospective study was done and the data of LOCP cancer patients, admitted during the year 2017 at Coimbatore Medical College Hospital was collected. A total of 441 LOCP cases were recorded, of which most cases belonged to the age group of 51-70 years and male gender. The most common subtypes are mouth and tongue. The increased incidence of LOCP cancer and its subtypes associated with smoking and tobacco points to the pivotal role of these risk factors in the pathogenesis of LOCP cancers. Hence better awareness and stringent measures is the need of the hour of the decrease the ongoing burden of these cancer types.