Nowadays, the population has been searching more and more for the services of the handling pharmacies, being them a form of access to personalized medicines. With this, it was sought to investigate the reliability of manipulated capsules in different pharmacies in the city of Manaus. The project is an analytical and observational research, of the transversal type, quantitative where the determination of the average weight was analyzed, as well as the test of disintegration of the samples. The criteria and specifications contained in the 6th edition of the Brazilian Pharmacopoeia were used, the data obtained from the tests of average weight were calculated the limits of variances and standard deviations for the tabulation in Excel® spreadsheet (Microsoft 2013), finally tables were assembled for the pharmacies. The results were examined and compared with the specifications pre-established in the 6th edition of the Brazilian Pharmacopoeia. The research indicated, with the data analysis, the quality rate of the capsules handled in handling pharmacies in Manaus, in relation to their disintegration time and their conformity to the average weight, which demonstrated the quality of the capsules analyzed.