Exposure to mycotoxin producing mold and mycotoxins can be associated with numerous adverse health consequences. We previously reported that patients with chronic illness frequently had a history of prior exposure to water damaged buildings (WDB) and mold. Additionally, the vast majority of these patients had mycotoxins present in the urine. We have postulated that the mycotoxin producing molds were likely harbored internally in the sinuses of these patients. In the present analysis, patients with chronic illness and a positive urine mycotoxin assay were treated with intranasal antifungal therapy, either amphotericin B (AMB) or itraconazole (ITR). AMB was associated with local (nasal) irritation adverse effects (AE) in 34% of the cases, which resulted in discontinuation. In patients that remained on therapy without AE, we found that 94% improved clinically. Additionally, we found that the urine mycotoxin levels decreased substantially in patients that improved on therapy. Similar findings were seen with ITR, however the number of patients treated was much smaller.

How to Cite
BREWER, DENNIS HOOPER, SHALINI MURALIDHAR, Joseph. Intranasal Antifungal Therapy in Patients with Chronic Illness Associated with Mold and Mycotoxins: An Observational Analysis. Global Journal of Medical Research, [S.l.], apr. 2015. ISSN 2249-4618. Available at: <https://medicalresearchjournal.org/index.php/GJMR/article/view/925>. Date accessed: 21 apr. 2019.

Organize Conference

We organize seminars /symposium /conferences/workshop/webinar worldwide on innovative topics and fields of Computer Science and research. We also collaborate, partner or sponsor with a view to provide our professional guidance and expertise to conduct in standard way.

Read More

Research Membership

Global Journals Inc., as described in our Corporate Statement, is an educational, research, research publishing, and professional membership organization. Elevation to the ranks of Fellow of the Association of the Research Society in Computer and Member of the Association of the Research Society in Computer is open.

Read More