Effect of Membrane Cholesterol on Glucose uptake in Diabetic Erythrocytes

Abstract

The generally observed common phenomenon of decreased utilization of glucose by tissue cells in type 2 diabetes mellitus is attributed to either lack of insulin or due to non availability of functioning insulin. Some of the recent studies indicate the decreased glucose utilization may be due to variations in the membrane lipid composition, there by altering glucose transport across the membrane possibly by disorienting the membrane transport molecules. Such a membrane lipid alteration may be due to diabetes induced dyslipidemia.