Waldenstrom's Macroglobulinema Presenting as Syncope

Ramy Sedhom

Authors

Ramy Sedhom

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Abstract

Syncope is a common complaint usually secondary to neurologic, cardiovascular, or orthostatic causes. However, rare etiologies are possible, implicating a great importance to history, physical examination, and interpretation of laboratory results and diagnostic workup. Waldenstrom's Macro- globulinema (WM) is a B-cell Lymphoma, hallmarked by an overproduction of IgM. Neurologic manifestations of WM include visual or auditory disturbances, headache, confusion, dizziness, vertigo, stroke and rarely, syncope. Neurologic presentations are a result of hyperviscosity or direct infiltration of malignant cells into the CNS. We present a case of Waldenstrom's Macroglublinema associated syncope.

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How to Cite

Waldenstrom’s Macroglobulinema Presenting as Syncope. (2016). Global Journal of Medical Research, 16(22), 37-38. https://medicalresearchjournal.org/index.php/GJMR/article/view/

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References

Lin P, Medeiros L (2005) Lymphoplasmacytic Lymphoma/ Waldenstrom Macroglobulinemia Advances in Anatomic Pathology. 12(5), 246-255.

Ansell S, Kyle R, Reeder C, Fonseca R, Mikhael J, Morice W (2010) Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk- Adapted Therapy (mSMART) Guidelines Mayo Clinic Proceedings. 85(9), 824-833. https://doi.org/10.4065/mcp.2010.0304

Ritzenthaler T, Leray V, Bourdin G, Baudry T, Domnisoru I, Ghesquières H (2013) Ventriculitis revealing Bing-Neel syndrome in a patient without Waldenstrom's macroglobulinemia Clinical Neurology and Neurosurgery. 115(1), 82-84. https://doi.org/10.1016/j.clineuro.2012.03.028

Sanchez-Guerrero J (2015) Bing-Neel syndrome: a rare complication of Waldenstrom macroglobulinemia Blood. 126(11), 1390-1390.

S. Stone MBogen (2011) Evidence-based focused review of management of hyperviscosity syndrome Blood. 119(10), 2205-2208.