Abstract

Anal fissure is a linear or oval shaped tear in the anal canal starting just below the dentate line extending to the anal verge. Topical glyceryltrinitrate cream a nitric oxide donor compound has been shown to cause relaxation of anal sphincter and thus effective in the treatment of anal fissure. Objective: The main goal is to evaluate the efficacy and complication of GTN with Vaseline base in period between January 2014 to June 2018 in Almak Nimir university hospital Shendi university (Sudan). Methodology: This study was a prospective, hospital based, small scale study conducted in the period between January 2014 to June 2018 in Almak Nimir university hospital Shendi university (Sudan). 155 patients with acute chronic anal fissure treated with GTN with Vaseline base (22 patients were excluded due to incomplete follow up). Result: One hundred and fifty-five patients were enrolled; twenty-two patients were excluded due incomplete follow up. Maximum number of cases of anal fissure in ano belonged to 21 to 30 age group. Success rate up to 94 % with and negligible site effect (1.5%). Conclusion: GTN 2% in Vaseline base was very effective in treatment of anal fissure with efficacy up to 94% and negligible site effect (1.5%).