A Diagnostic Challenge in a Patient with Intractable Nausea and Vomiting: A Case of Systemic Amyloidosis
Keywords:
Abstract
Amyloidosis is a rare disorder caused by deposition of amyloid fibrils in various tissues causing structural and functional defects. Depending upon organs involved, it may be categorized as localized or systemic. Systemic amyloidosis involves multiple organs where some organs are affected more commonly than others. Diagnosis is often challenging as in a 76-yearsold female described here who presented with intractable nausea and vomiting. Clinical course was complicated because of simultaneous presence of peptic ulcer disease and hypothyroidism. Involvement of multiple systems including gastrointestinal tract, thyroid, liver, heart and kidneys was seen, and diagnosis was achieved after renal biopsy showing Congo red staining and apple green birefringence. Gastric and thyroid infiltration by amyloidosis are extremely rare occurrences described very infrequently in the literature. However, to our knowledge, involvement of both organs in a single patient has not been reported in the literature.
Downloads
- Article PDF
- TEI XML Kaleidoscope (download in zip)* (Beta by AI)
- Lens* NISO JATS XML (Beta by AI)
- HTML Kaleidoscope* (Beta by AI)
- DBK XML Kaleidoscope (download in zip)* (Beta by AI)
- LaTeX pdf Kaleidoscope* (Beta by AI)
- EPUB Kaleidoscope* (Beta by AI)
- MD Kaleidoscope* (Beta by AI)
- FO Kaleidoscope* (Beta by AI)
- BIB Kaleidoscope* (Beta by AI)
- LaTeX Kaleidoscope* (Beta by AI)
How to Cite
References
R Falk, R Comenzo, M Skinner (1997) The Systemic Amyloidoses. 337, 898-909.
G Merlini, V Bellotti (2003) Molecular Mechanisms of Amyloidosis. 349, 583-596.
Raymond Comenzo (2009) How I treat amyloidosis. 114(15), 3147-3157.
Nelson Leung, Samih Nasr, Sanjeev Sethi (2012) How I treat amyloidosis: the importance of accurate diagnosis and amyloid typing. 120(16), 3206-3213.
Prayman Sattianayagam, Philip Hawkins, Julian Gillmore (2009) Amyloid and the GI tract. 3(6), 615-630.
S Petre, I Shah, N Gilani (2008) Review article: gastrointestinal amyloidosis: clinical features, diagnosis and therapy. 27(11), 1006-1016.
A Cowan, M Skinner, D Seldin, J Berk, D Lichtenstein, C O'hara, G Doros, V Sanchorawala (2013) Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience. 98(1), 141-146.
S Said, K Grogg, T Smyrk (2015) Gastric amyloidosis: clinicopathological correlations in 79 cases from a single institution. 46(4), 491-498.
David Menke, Robert Kyle, C Fleming, James Wolfe, Paul Kurtin, Warner Oldenburg (1993) Symptomatic Gastric Amyloidosis in Patients With Primary Systemic Amyloidosis. 68(8), 763-767.
R Leong, K Nio, L Plumley, E Molmenti, Jds Klein (2014) Systemic amyloidosis causing intestinal hemorrhage and pseudo-obstruction. (9), 87.
Rachel Koppelman, Neil Stollman, Francisco Baigorri, Arvey Rogers (2000) Acute small bowel pseudo-obstruction due to AL amyloidosis: a case report and literature review. 95(1), 294-296.
Konstantinos Liapis, Fotios Michelis, Sosanna Delimpasi, Themistoklis Karmiris (2011) Intestinal pseudo-obstruction associated with amyloidosis. 18(2), 76-78.
K Katsanos, N Tzambouras, D Christodoulou, E Tsianos, K Bourantas (2000) Acute small bowel pseudo-obstruction due to AL-amyloidosis. 95(11), 3329-3331.
M Rich (1995) Hypothyroidism in association with systemic amyloidosis. 17(4), 343-345.
M Siddiqui, M Gertz, D Dean (2007) Amyloid goiter as a manifestation of primary systemic amyloidosis. 17(1), 77-80.
G Hamed, C Heffess, B Shmookler, B Wenig (1995) Amyloid goiter. A clinicopathologic study of 14 cases and review of the literature. 104(3), 306-312.
Miguel Park, Paul Mueller, Robert Kyle, Dirk Larson, Matthew Plevak, Morie Gertz (2003) Primary (AL) Hepatic Amyloidosis. 82(5), 291-298.
Yong Shin (2011) Hepatic amyloidosis. 17(1), 80.
R Son, J Chang, J Choi (2011) Primary hepatic amyloidosis: report of an unusual case presenting as a mass. 12(3), 382-385.
Y Wang, C Zhao, H Yin (2012) Primary hepatic amyloidosis: a mini literature review and five cases report. 11(5), 721-727.
S Dubrey, K Cha, J Anderson (1998) The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement. 91(2), 141-157.
Simon Dubrey, Karen Cha, Robert Simms, Martha Skinner, Rodney Falk (1996) Electrocardiography and Doppler echocardiography in secondary (AA) amyloidosis. 77(4), 313-315.
M Gertz, R Comenzo, R Falk (2005) Definition of organ involvement and treatment response in immunoglobulin light-chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis. 79, 319-328.
M Khalighi, W Wallace, Palma-Diaz Mf (2014) Amyloid nephropathy. 7(2), 97-106.
H Von Hutten, M Mihatsch, H Lobeck, B Rudolph, M Eriksson, C Röcken (2009) Prevalence and origin of amyloid in kidney biopsies. 33(8), 1198-1205.
E Desport, F Bridoux, C Sirac (2012) Unknown Title. 7, 54.
Published
2016-01-06
Issue
Section
License
Copyright (c) 2015 Authors and Global Journals Private Limited
This work is licensed under a Creative Commons Attribution 4.0 International License.