A Study of the Psychotropic Activity of Extracts of Hedysarum  Alpinum L. and Garcinia Mangostana L.

Fedorova Yu.S.; Kulpin P.V.; Suslov N.I.; Denisova S.V; Tretyak V.M.; Merkuryeva A.G.

Authors

Fedorova Yu.S.
Kulpin P.V.
Suslov N.I.
Denisova S.V
Tretyak V.M.
Merkuryeva A.G.

Keywords:

Hedysarum alpinum L, Garcinia mangostana L, active avoidance conditioning

Abstract

The present research featured extracts of Hedysarum alpinum L. and Garcinia mangostana L. The extract of Hedysarum alpinum L. proved to have a more pronounced effect on the dopamine-induced changes in animal behavior in an active avoidance conditioning model as compared with such popular antipsychotic drug as haloperidol. Methodology: The antipsychotic effect was evaluated based on active avoidance conditioning model in a two-compartment shuttle chamber. The anti-anxiety effect was evaluated in terms of passive avoidance conditioning. The side depressive effect of the extracts was evaluated based on the behavior of the animals during the Open Field test.

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How to Cite

A Study of the Psychotropic Activity of Extracts of Hedysarum Alpinum L. and Garcinia Mangostana L. (2020). Global Journal of Medical Research, 20(B4), 7-13. https://medicalresearchjournal.org/index.php/GJMR/article/view/2063

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References

M Cherepnev, S Gracheva (1991) Threats Related to the Use of Quantum Effects in Cryptography. 30(8), 417-424.

D Casey (1996) Side effect profiles of new antipsychotic agents. 57(11), 40-45.

Wei Wang, Yu-Ying Zhao, Hong Liang, Qi Jia, Hu-Biao Chen (2006) Coumestans from Hedysarum multijugum. 69(6), 876-880.

Gershon Elison, A (1983) Anxiolytic Profiles. 44(11), 45-56.

P Jones, P Buckley, Schizophrenia (2006) Unknown Title. 128.

C Koch (2004) A The Quest for Consciousness: A Neurobiological Approach. 429.

Francisco López-Muñoz, Cecilio Alamo, Eduardo Cuenca, Winston Shen, Patrick Clervoy, Gabriel Rubio (2005) History of the Discovery and Clinical Introduction of Chlorpromazine. 17(3), 113-135.

J Quan (1998) Protective effect of Astragalus membranaceus (Fishc.) Bge. and Hedysarum polybotrys Hand.-Mazz. on experimental model of cerebral ischemia in rats // Zhonggo Zhong Yao. 23, 371-373.

Roger Walsh, Robert Cummins (1976) The open-field test: A critical review.. 83(3), 482-504.

A Aliforenko, V Bykov, А Bykova, V Motov, K Kozhukhovskiy, V Pavlovskiy, V Khazanov, A Vengerovskii (2013) Pharmacokinetics of the bradykinin antagonist derivative 1,4-benzodiazepin-2-one in the experiment. 7(4), 124-137.