Protective Effects of Diallyl Disulfide Against Experimentally Induced Hepatoma in Mice

Abstract

Many herbal extracts have been reported to modify significantly the transformation of normal cells into neoplastic cells Garlic and its extracts are known for their hypolipidemic hypoglycemic antiplatelet aggregating effect as well as for its anticancer effects Many of these health beneficial effects of garlic are attributed to its principle organosulfur compound diallyl disulfide DADS It was thought that DADS may be involved in anticarcinogenic antitumorogenic effect of garlic hence the present work was undertaken to assess the protective effects of DADS in ehrlich ascites carcinoma EAC cells induced hepatoma in mice The study has three groupsnormal group group1 the EAC cells implanted mice group 2 DADS-treated EAC cells implanted mice group 3 The results indicate a significant decrease in ascitic fluid volume ascitic fluid cell count liver tissue amino acid nitrogen levels liver tissue glutaminase activity liver tissue lactate levels as well as a increase in life span observed in group 3 mice as compared to group 2 mice suggesting that DADS gives a significant protection in group3 mice probably by decreasing the anaerobic glucose utilization as well as by interfering with protein deoxy ribonucleotide synthesis