Design and Evaluation of a 3-Component Composite Excipient aoMicrocrystarcellaca as a Filler-Binder for Direct Compression Tabletting and its Utilisation in the Formulation of Paracetamol And Ascor
Keywords:
Microcrystarcellac, Coprocessed Excipient, Directly compressible Excipient, Highly functional Filler-binder, Microcrystalline Tapioca Starch
Abstract
A research was conducted to design and evaluate a highly functional 3-component composite fillerbinder for direct compression. Tapioca starch (NTS) was modified physically at molecular level by annealing and enzyme hydrolyzed to obtain microcrystalline tapioca starch (MCTS) which was coprocessed with LMH and microcrystalline cellulose (MCC) to yield Microcrystarcellac (MSCL). NTS was extracted from cassava tuber ( Mannihot esculenta crantz ) using a standard method. The powder suspensions were prepared in concentration of 40 %w/w in five separate conical flasks. The starch granules were annealed for 1 h and subsequently hydrolyzed with α-amylase at 58o and pH 7 for 1, 2, 3, 4, and 5 h in a water bath. The reaction was terminated and neutralized with 0.1 N HCL and 0.1 N NaOH respectively. The MCTS was washed, recovered by sedimentation and air dried at room temperature for 72 h.
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References
I Casahoursat, G Lemagen, D Larrouture (1998) The use of Stress Relaxation Trials to Characterize Tablet Capping. 14(15 -17), 2179-2199.
J Radley (1976) Starch Production Technology. 587.
M Grace (1977) Cassava Processing.
Tuangporn Tukomane, Prakan Leerapongnun, Sujin Shobsngob, Saiyavit Varavinit (2007) Preparation and Characterization of Annealed‐Enzymatically Hydrolyzed Tapioca Starch and the Utilization in Tableting. 59(1), 33-45.
Tsuimin Tsai, Jen-Sen Wu, Null- Ho, Ming-Thau Sheu (1998) Modification of Physical Characteristics of Microcrystalline Cellulose by Codrying with β-Cyclodextrins. 87(1), 117-122.
R Heckel (1961) Density-Pressure relationships in Powder Compaction. 221, 671-675.
Kimio Kawakita, Karl-Helmut Lüdde (1970) Some considerations on powder compression equations. 4(2), 61-68.
Vijay Kumar, Sanjeev Kothari (1999) Effect of compressional force on the crystallinity of directly compressible cellulose excipients. 177(2), 173-182.
J Fell, J Newton (1970) Determination of Tablet Strength by the Diametral-Compression Test. 59(5), 688-691.
P Paronen, M Juslin (1983) Compression Charateristic of Four Starches. 35, 627-635.
A Mitrevej, N Sinchaipanid, D Faroongsang (1996) Spray-Dried Rice Starch: Comparative Evaluation of Direct Compression Fillers. 22, 587-594.
R Roberts, R Rowe (1985) The Effect of Punch Velocity on the Compaction of a Variety of Materials. 37, 377-384.
K Khan, C Rhodes (1973) The Production of Tablets by Direct Compression. 8, 5.
Shikifumi Kitazawa, Ikuo Johno, Tokuzo Minouchi, Jutaro Okada (1977) Interpretation of dissolution rate data from in vitro testing of compressed tablets. 29(1), 453-459.
Christer Nyström, Göran Alderborn, Margareta Duberg, Per-Gunnar Karehill (1993) Bonding Surface area and Bonding Mechanism-Two Important Factors fir the Understanding of Powder Comparability. 19(17-18), 2143-2196.
C Lin, T Cham (1995) Compression Behaviour and Tensile Strength of Heat-treated Polyethylene glycols. 118, 169-179.
Padmaja Shivanand, Omar Sprockel (1992) Compaction behavior of cellulose polymers. 69(2), 177-184.
O Odeku, O Itiola (1998) Evaluation of Khaya Gum as a Binder in a Paracetamol Formulation. 4, 183-188.
R Shangraw, J Wallace (1981) Morphology and Functionality in Tablet Excipients for Direct Compression: Part 1. 5(9), 69-78.
M Duberg, C Nyström (1986) Studies on direct compression of tablets XVII. Porosity-pressure curves for the characterization of volume reduction mechanisms in powder compression. 46(1), 67-75.
O Itiola (1991) Compressional Characteristics of Three Starches and the Mechanical Properties of their Tablets. 8(3), 91-94.
(2007) Direct Compression and the Role of Filler-binders. 6, 189-232.
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2012-08-19
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