Evaluation and Ranking of Drug Release from Different Grades of Guar Gum, Acacia Gum and Polyvinyl Pyrrolidone as Cross-Linkers in Submicron Particles

Abstract

Due to their unique properties nanoparticles made of polysaccharides are promising carriers to deliver and protect the physiological properties of hydrophilic drugs They have been successfully applied as drug delivery systems 83 Objective The main goal of this research is to Improve Carbamazepine water solubility and drug release properties by nano sizing and using guar gum Acacia Gum and poly-vinylpyrrolidone each of two viscosity grades as crosslinking agents Moreover the study is extrapolated utilizing composite index CI design and mathematical modelling in an attempt to locate the most suitable set of the factors that affect nanoparticles produced with optimum specifications