Abstract

Triazines and chalcones are interesting class of heterocyclic compounds with a prominent structural core system present in numerous pharmacologically active compounds It is proved from the literature that the compounds containing 1 3 5-triazine moiety or chalcone bridge often shows significant biological activity profiles Based on these observations it was considered worthwhile to synthesize and characterize some new 1 3 5-triazine-chalcone hybrid molecules in the present investigation As a part of our research program aimed at search for new hybrid pharmacophores as potential cytotoxic agents we are interested to have -unsaturated ketone linker to the 1 3 5-triazine basic nucleus to give a series of 1 3 5-triazine-chalcone hybrid molecules Therefore in the present study an attempt has been made to synthesize and characterize various analogs of fully unsaturated 2-substituted-4 6 dichloro-1 3 5 triazine based chalcone hybrids