Erythrocyte membrane lipid alteration in type 2 Diabetic subjects

Basavaraj Aski; Kashinath.R.T

Authors

Basavaraj Aski
Kashinath.R.T

Keywords:

membrane cholessterol, membrane phosplipids, membrane Phospholipids/ cholesterol ratio

Abstract

The lipid components present in biological membranes including erythrocyte membrane are significant in regulation of the membrane fluidity as well as transport across the membranes. The conflicting results of either increase or decrease or no change have been reported in erythrocyte membrane fluidity in type 2 diabetic subjects. The diabetes induced dyslipidemia possibly lead to an alteration in erythrocyte membrane lipid composition. Hence a study was undertaken to assess erythrocyte membrane lipid alterations in type 2 diabetic subjects. The blood samples from randomly selected type 2 diabetic subjects, attending Medical OPD of Basaveshwara Medical College Hospital, Chitradurga, were collected with heparin as an anticoagulant. Erythrocyte membrane total cholesterol (mTC), Erythrocyte membrane phospholipids (mPL), Erythrocyte membrane phosphatidyl choline, Erythrocyte membrane sphingomyelin and Erythrocyte membrane phospholipids/ Erythrocyte membrane cholesterol ratio were studied. The results suggests a significant rise in erythrocyte membrane cholesterol (mTC, N=1.25±0.31, T2DM= 1.54± 0.14, p

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How to Cite

Erythrocyte membrane lipid alteration in type 2 Diabetic subjects. (2011). Global Journal of Medical Research, 11(3), 19-23. https://medicalresearchjournal.org/index.php/GJMR/article/view/113

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References

Y Alester, A Lowenstein, S Leven, M Lazar, R Korenstein (1998) Low-frequency submicron fluctuation of red blood cells in diabetic retinopathy. 116, 1321-1325.

Y Baba, M Kai, T Kamada, S Setoyama, S Otsuji (1979) Higher levels of erythrocyte membrane microviscosity in diabetes. 28(12), 1138-1140.

P Baldini, S Incerpi, S Lambert-Gordin, A Spinedi, P Luly (1989) Membrane lipid alterations and Na+ pumping activity in erythrocyte from IDDM and NIDDM subjects. 38, 825-831.

S Balls, S Krasnow (1980) Structure of erythrocyte membrane and its transport function. 10, 209-219.

M Bryszewska, Leykow (1983) Effect of insulin on human erythrocyte membrane fluidity in diabetes mellitus. 24, 311-313.

M Bryszewska, Weataly, W Torsksae (1986) Changes in fluidity and composition of erythrocyte membrane and in composition of plasma lipid in Type I diabetes. 62, 11-116.

D Chapman (1968) Recent physical studies of phospholipid and natural membranes. 125-202.

K Choudhary (1989) Biochemical Techniques. 112-114.

Dang Aq, F Fass, W Corter (1984) Unknown Title. 19, 738-748.

C Fiske, Subba Row, Y (1925) Analysis of Erythrocyte Membrane Lipid Alteration in Type 2 Diabetic Subjects phosphorous profile by TLC. 234, 375.

G Gulliver (1862) Blood of Vertebrata.

Herold Varley (1969) Determination of Cholesterol.

Juhan Vagus, J Dris, Roul Cedel (1984) Abnormalities of erythrocyte membrane lipids in insulin dependent diabetes are improved by shorter term control of diabetes. 455-459.

Donald Mcmillan, Nyle Utterback, John Puma (1978) Reduced Erythrocyte Deformability in Diabetes. 27(9), 895-901.

P Miossec, F Zkhiri, J Pariès, M David‐dufilho, M Devynck, P Valensi (1999) Effect of pravastatin on erythrocyte rheological and biochemical properties in poorly controlled Type 2 diabetic patients. 16(5), 424-430.

Z Mishal, C Roll, R Mouray, Yi, M Allaud, P Vague (1986) Correction by insulin and in vitro of abnormal membrane fluidity of (Type 1) diabetic patient. 29, 29417-29420.

(2011) Unknown Title.

R Nath (1990) Practical Biochemistry in clinical medicine 2 nd edn. 120.

U Ruiz-Gutierrez, P Satiefel, J Villar, M Garcia Donas, D Acastaq, Carneado (1993) Unknown Title. 36, 850-856.

H Schmit-Schonbein, E Volger (1976) Red cell aggregation and red cell deformability in diabetes. 25, 897-902.

M Shamalam, Neela Reshamwala, Patil (2005) Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus. 21. 42, 250-253.

T Konak Sekiya, M (1979) Unknown Title. 6, 363-369.

G Steiner (1994) The dyslipoproteinemias of diabetes atherosclerosis. 110, 527-533.

Gerald Tomkin (1994) Targets for Intervention in Dyslipidemia in Diabetes. 31(Supplement_2), S241-S248.

S Tsakiris, G Deliconstantinos (1984) Influence of phosphatidylserine on (Na+ + K+)-stimulated ATPase and acetylcholinesterase activities of dog brain synaptosomal plasma membranes. 220(1), 301-307.

U K Ukpds Group (1994) UK Prospective Diabetes Study (UKPDS) XI: Biochemical Risk Factors in Type 2 Diabetic Patients at Diagnosis Compared with Age‐matched Normal Subjects. 11(6), 534-544.

J Verklij, Zwaal R F (1973) The asymmetric distribution of phospholipids in the human red cell membrane. 323, 178-193.

R Wali, S Jafe, D Kumar, V Kalra (1988) Unknown Title. 37, 104-111.

D Wilson, W Kannel, K Anderson (1985) Lipids, Glucose tolerance and Vascular Disease; The Framingham study, monogr. 13, 1-11.

T Shiga, N Maeda, Suda, S Oka Unknown Title.