Anti-Hyperglycemic and in Vivo Antioxidant Activities of Aqueous Extract of Blighia sapida Stem Bark in Alloxan-Induced Diabetic Rats

Authors

  • Amira Philip Olaniyi

Keywords:

blighiasapida, diabetes, antioxidant enzymes, epidemic, biomolecules

Abstract

Blighiasapida is a plant belonging to the family of Sapindaceae. This study is aimed at evaluating the hypoglycemic and possible in vivo antioxidant activities of the aqueous extract of the stem bark of the plant for 21 days in alloxan-induced diabetic rats. Administration of the extract at 100mg/kg body weight significantly (P

How to Cite

Anti-Hyperglycemic and in Vivo Antioxidant Activities of Aqueous Extract of Blighia sapida Stem Bark in Alloxan-Induced Diabetic Rats. (2017). Global Journal of Medical Research, 17(B1), 15-23. https://medicalresearchjournal.org/index.php/GJMR/article/view/1278

References

(1316) Saturday, 6 June 2015 08:30-10:00 Hall A S‐05 Diet and functional gastrointestinal disorders. 27(S2), 12-13.

I Abdel-Hassan, J Abdel-Barry, Tariq Mohammeda, S (2000) The hypoglyceamic and antihyperglyceamic effect of Citrulluscolocyntis fruit aqueous extract in normal and alloxan diabetic rabbits. 71(1-2), 325-330.

O Aderinola, G Farinu, J Akinlade, T Olayemi, O Ojebiyi, P Ogunniyi (2007) Nutritional Potential of Blighiasapida K Konig (Ackeeakkee) leaves as a dry season feed resources for West Africa dwarf goats in the derived savanna zone of Nigeria. 19(6), 78.

D Adeyemi, O Komolafe, O Adewole, E Obuotor, T Adenowo (2009) Antihyperglycemic Activities of Annonamuricata (Linn). 6(1), 62-69.

H Aebi (1984) Catalase in vitro. 105, 121-126.

N Altan, Sepici-Dincel, C Koca (2006) Diabetes mellitus and oxidative stress. 31, 51-56.

J Baynes, S Thorpe (1999) Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. 48(1), 1-9.

E Beatler, O Duron, B Kelly (1963) Improved method for the determination of blood glutathione. 61, 882-888.

J Blum, I Fridovich (1985) Inactivation of glutathione peroxidase by superoxide radical. 240, 500-508.

M Brownlee (2001) Biochemistry and Molecular cell biology of Diabetic complications. 414(6865), 813-820.

J Evans, I Goldfine, B Maddux, G Grodsky (2003) Are Oxidative stress-activated signaling pathways mediators of insulin resistance and -cell dysfunction?. 52, 1-8.

M Gardiner, L William, T The, C Fletcher, P Singh, G Wharfe, E Choo-Kang, R Sawh, E Rickards (1996) Extracts from Blighiasapida (Koenig) produce neutropenia and thrombocytopenia in mice. 10, 689-691.

Dario Giugliano, Raffaele Marfella, Ludovico Coppola, Giovanni Verrazzo, Rita Acampora, Riccardo Giunta, Francesco Nappo, Carmela Lucarelli, Felice D'onofrio (1997) Vascular Effects of Acute Hyperglycemia in Humans Are Reversed byl-Arginine. 95(7), 1783-1790.

C Hall, S Cuppet (1997) Activities of Natural antioxidants. II, 2-20.

David Harrison, Kathy Griendling, Ulf Landmesser, Burkhard Hornig, Helmut Drexler (2003) Role of oxidative stress in atherosclerosis. 91(3), 7-11.

D Holme, H Peck (1998) Analytical Biochemistry.

H Kaneto, N Katakami, M Matsuhisa, T Matsuoka (2010) Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis. 1-11.

A Khan, F Gumbs (2003) Repellent effect of ackee (BlighiasapidaKaonig) component fruit parts against stored product insect pests. 80, 19-27.

R Larson (1988) The antioxidants of higher plants. 27, 969-978.

R Levine, D Garland, C Oliver, A Amici, I Climent, A Lenz, B Ahn, S Shaltiel, E Stadtiana (1990) Determination of carbonyl content in Oxidatively modified proteins. 186, 464-478.

O Lowry, N Rosenberg, A Farr, R Randal (1951) Protein measurement with the Folin-phenol reagent. 193, 265-275.

R Marfella, G Verrazzo, R Acampora, C La Marca, R Giunta, C Lucarelli, G Paolisso, A Ceriello, D Giugliano (1995) Glutathione reverses systemic hemodynamic changes induced by acute hyperglycemia in healthy subjects. 268(6), E1167-E1173.

J Mccord, I Fridovich (1969) Superoxide Dismutasse, AnEnzymic function for Erythrocuprein (Hemocuprein). 244, 6049-6055.

K Mohazzab, P Kaminski, M Wolin (1994) NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. 266(6), H2568-H2572.

Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. 95(2), 351-358.

D Okwu, A Antai, K Udofia, A Obembe, K Obasi, M Eteng (2006) Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats. 31(5), 570-575.

A Oladiji, K Shoremekun, M Yakubu (2009) Physicochemical Properties of the Oil from the Fruit of Blighia sapida and Toxicological Evaluation of the Oil-Based Diet in Wistar Rats. 12(5), 1127-1135.

G Paolisso, D Giugliano (1996) Oxidative stress and insulin action: is there a relationship?. 39, 257-263.

J Rotruck, A Pope, H Ganther, A Swanson, D Hafeman, W Hoekstra (1973) Selenium: Biochemical Role as a Component of Glutathione Peroxidase. 179(4073), 588-590.

A Saidu, A Mann, C Onuegbu (2012) Phytochemical Screening and Hypoglycemic Effect of Aqueous Blighia sapida Root Bark Extract on Normoglycemic Albino Rats. 2(2), 89-97.

A Scoppola, F Montechi, G Mezinger, S Gasset (2003) The effect of Gangronemalatifolium extract on serum lipid profile and oxidative stress in hepatocytes of diabetic rats. 28(1), 1-5.

A Sepici-Dincel, S Acikgoz, C Cevik, M Sengelen, E Yesilada (2007) Effects of in vivo antioxidant enzyme activities of mytle oil in normoglycaemic and alloxan diabetic rabbits. 110, 498-503.

A Srividya, S Dhanabal, Satish Kumar, M, Parth Kumar, H (2010) Antioxidant and Antidiabetic Activity of Alpiniagalanga. 3(1), 6-12.

T Sunmonu, A Afolayan (2013) Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afra Aqueuos Extract in Wistar Rats. 2013, 929074.

N Ugochukwu, N Babady, M Cobourne, S Gasset (2003) The effect ofGongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats. 28(1), 1-5.

N Unwin, E Sobngwi, K Alberti (2001) Type2 diabetes: the challenge of preventing a global epidemic. 4-8.

Christine Weydert, Joseph Cullen (2009) Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. 5(1), 51-66.

Who (2000) Dye, Dr Christopher, (born 15 April 1956), Director of Strategy, Office of Director General, World Health Organization, Geneva, since 2014.

Anti-Hyperglycemic and in Vivo Antioxidant Activities of Aqueous Extract of Blighia sapida Stem Bark in Alloxan-Induced Diabetic Rats

Published

2017-05-11

How to Cite

Anti-Hyperglycemic and in Vivo Antioxidant Activities of Aqueous Extract of Blighia sapida Stem Bark in Alloxan-Induced Diabetic Rats. (2017). Global Journal of Medical Research, 17(B1), 15-23. https://medicalresearchjournal.org/index.php/GJMR/article/view/1278