Adaptogenic Activity of Morus Alba Extracts in Wistar Rats

Dr. Somayeh Afsah Vakili

Authors

Dr. Somayeh Afsah Vakili

Keywords:

morus alba, stress, homovanillic acid, urinary vanillymandelic acid, 6-?-OH-cortisol, 5-hydroxyindo- leacetic acid, ascorbic acids

Abstract

Morus alba was broadly used with a long history of traditional medicinal remedy for the regimen of various illnesses. The current investigation was designed to evaluate anti-stress activity of aqueous and ethanol extracts of Morus alba. Anti-stress of aqueous and ethanol extracts of Morus alba was estimated by inducing stress in rats through the forceful swimming. Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid were reckoned as non-invasive biomarkers to assess the adaptogenic activity. Daily oral administration of aqueous and ethanol extracts of Morus alba at dose of 200 and 400 mg/kg body weight one hour before the induction of stress to retard stress-induced urinary biochemical changes in a dose dependent manner. However, non-significant changes in the urinary excretion of Homovanillic acid (HVA), urinary vanillymandelic acid (VMA), 6-β-OH-cortisol, 5-hydroxyindoleacetic acid (5HIAA) and ascorbic acid was perceived when compared to basal levels in normal animals.

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How to Cite

Adaptogenic Activity of Morus Alba Extracts in Wistar Rats. (2017). Global Journal of Medical Research, 17(B3), 21-29. https://medicalresearchjournal.org/index.php/GJMR/article/view/1364

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