Abstract

Introduction: Bladder TCC is rare in young adults and occurs more commonly in elderly individuals. The incidence of TCC urinary bladder is found to be 1% - 2.4% among young adults less than 40 years of age. Younger population has incidence of only .1% - .4% (age less than 20 yrs). Present study aimed to compare the clinical behavior, pathologic characteristics and prognosis of TCC urinary bladder in population between #x2264; 30 and 31-40 yrs. Methods: A retrospective review of our records between Jan 2006 and Dec 2012 identified 71 patients with TCC bladder who were less than 40 years old. Clinical and pathological parameters of patients who were #x2264; 30 years of age were compared with those of a series of patients between 31- 40 years of age during the same period. Results: Multivariate logistic regression analysis revealed high tumor grade and multifocality as predominant predictors of tumor recurrence in young patients. A Significant difference was observed in the recurrence-free (p lt;.018) and progression- free (p lt; 0.06) survival rates between the two groups. Conclusion: We concluded that although the clinical stage distribution, natural history, and outcomes of bladder TCC in young adults are similar to those in their older counterparts, Clinicians must be aware that patients with higher-grade and multifocal tumors are more likely to experience tumor recurrence and grade progression.