Nicotine Induced Liver Toxicity in Wistar Albino Rats: Protective Effects of Aqueous Extract of Moringa Olifera (Lam)

Olatunde Abass Oseni; Akindolire Olajumoke; Musbau Aderonke

Authors

Olatunde Abass Oseni
Akindolire Olajumoke
Musbau Aderonke

Keywords:

moringaolifera, nicotine, hepatotoxicity, antioxidant property, lipid profile

Abstract

Aqueous extract of Moringaolifera (Lam) was evaluated for protective and antioxidant activities in rats. The plant extract showed a remarkable chemo-protective activity on nicotine induced liver toxicity as judged by serum maker enzyme and some antioxidant levels in the liver of male albino rats weighing between 180 and 200g. The animals were grouped into five of six rats each which were intraperitoneally induced with nicotine at 1mg/kg body weight except the control group. Some biochemical parameters (Aspartate aminotransferase (AST), Alanineaminotransferase (ALT), alkaline phosphatase (ALP), creatinine kinase malondialdehyde (MDA)); some antioxidant indices and lipid profiles were monitored. Induction of nicotine produced a significant increase in the level of malondialdehyde and decrease in the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) as compared to the control animals. Treatment with aqueous extract of Moringaoleifera leaf was found to produce a significant decrease in TBARS and increase in GSH, SOD and CAT in the plasma and liver homogenate of the nicotine induced rats. The levels of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol in plasma and hepatic tissues of the experimental animals were also monitored. Significant protection was seen in the extract and standard drug (Lisinopril) treated nicotine induced animals. Administration of aqueous extract of the plant brings about a significant restoration towards the control values.

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Nicotine Induced Liver Toxicity in Wistar Albino Rats: Protective Effects of Aqueous Extract of Moringa Olifera (Lam). (2018). Global Journal of Medical Research, 18(B4), 23-27. https://medicalresearchjournal.org/index.php/GJMR/article/view/1585

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References

N Lindenblatt, U Platz, J Hameister, E Klar, Mengermd, B Vollmar (2007) Distinct effects of acute and chronic nicotine application on microvascular thrombus formation and endothelial function in male and female mice. 392, 285-295.

Paul Lau, Lan Li, Aksam Merched, Alan Zhang, Kerry Ko, Lawrence Chan (2006) Nicotine Induces Proinflammatory Responses in Macrophages and the Aorta Leading to Acceleration of Atherosclerosis in Low-Density Lipoprotein Receptor^−/−Mice. 26(1), 143-149.

Gregory Albaugh, Emily Bellavance, Louise Strande, Stacy Heinburger, Charles Hewitt, James Alexander (2004) Nicotine Induces Mononuclear Leukocyte Adhesion and Expression of Adhesion Molecules, VCAM and ICAM, in Endothelial Cells In Vitro. 18(3), 302-307.

David Rubenstein, Jolyon Jesty, Danny Bluestein (2004) Differences Between Mainstream and Sidestream Cigarette Smoke Extracts and Nicotine in the Activation of Platelets Under Static and Flow Conditions. 109(1), 78-83.

Farooq Anwar, Sajid Latif, Muhammad Ashraf, Anwarul Gilani (2007) Moringa oleifera: a food plant with multiple medicinal uses. 21(1), 17-25.

S Ghasi, E Nwobodo, J Ofili (2000) O: Hypocholesterolemic effects of crude extract of leaf of Moringaoleifera Lam in high-fat diet fed wistar rats. 69, 21-25.

Pankaj Tahiliani, Anand Kar (2000) ROLE OF MORINGA OLEIFERA LEAF EXTRACT IN THE REGULATION OF THYROID HORMONE STATUS IN ADULT MALE AND FEMALE RATS. 41(3), 319-323.

E Makonnen, A Hunde, G Damecha (1997) Hypoglycaemic Effect ofMoringa stenopetala Aqueous Extract in Rabbits. 11(2), 147-148.

Saroj Pal, Pulok Mukherjee, B Saha (1995) Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats. 9(6), 463-465.

R Bharali, J Tabassum, M Rekibul, H Azad (2003) Chemomodulatory Effect of Moringa Oleifera, Lam, on Hepatic Carcinogen Metabolising Enzymes, Antioxidant Parameters and Skin Papillomagenesis in Mice. 4, 131-139.

Shaheen Faizi, Bina Siddiqui, Rubeena Saleem, Salimuzzaman Siddiqui, Khalid Aftab, Anwar-Ul-Hassan Gilani (1995) Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. 38(4), 957-963.

S Mahajan, A Mehta (2008) A: Effect of MoringaoleiferaLam. seed extract on ovalbumininduced airway inflammation in guinea pigs. 20, 897-909.

K Rao, S Mishra (1998) H: Anti-Inflammatory and antihepatoxic activities of the roots of Moringapterygosperma Gaertn. 60, 12-16.

U Mazumder, M Gupta, S Chakrabarti, D Pal (1999) Evaluation of hematological and hepatorenal functions of methanolic extract of Moringaoleifera Lam. Root Treated Mice. 37, 55-60.

Richard Bennett, Fred Mellon, Nikolaus Foidl, John Pratt, M Dupont, Lionel Perkins, Paul Kroon (2003) Profiling Glucosinolates and Phenolics in Vegetative and Reproductive Tissues of the Multi-Purpose Trees Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L.. 51(12), 3546-3553.

Hirofumi Tanaka, Kevin Monahan, Douglas Seals (2001) Age-predicted maximal heart rate revisited. 37(1), 153-156.

A El-Khatib, M Mansour (2013) A: Prior treatment with captopril attenuates carbon tetrachloride-induced liver injury in mice. 110(1-2), 3-16.

K Blanchard, Clay, Morris (1996) Pulmonary activation and toxicity of cyclopentadienyl manganese tricarbonyl. 136, 280-288.

L Morandi, C Angelini, A Prelle, A Pini, B Grassi, G Bernardi, L Politano, C Bruno, D De Grandis, P Cudia, A Citterio (2006) High plasma creatine kinase: review of the literature and proposal for a diagnostic algorithm. 27(5), 303-311.

Milica Vukovic, Catarina Sepulveda, Chithra Subramani, Amélie Guitart, Jasmine Mohr, Lewis Allen, Theano Panagopoulou, Jasmin Paris, Hannah Lawson, Arnaud Villacreces, Alejandro Armesilla-Diaz, Deniz Gezer, Tessa Holyoake, Peter Ratcliffe, Kamil Kranc (2016) Adult hematopoietic stem cells lacking Hif-1α self-renew normally. 127(23), 2841-2846.

K Husain, S Somani (1997) Response of cardiac antioxidant system to alcohol and exercise training in the rat. 14(3), 301-307.

B El-Sayed, A Eslam (2014) H: Effect of Aqueous Extract of Green Tea (Camellia sinensis L.) on Obesity and Liver Status in Experimental Rats. 21(2), 53-63.