The reliable diagnostic identification of neuropsychiatric disorders such as schizophrenia, bipolar disease, and depression has been associated with some biological markers (genomics, proteomics, metabolomics) but to date, these markers do not have the sensitivity/specificity of a diagnostic test. Biomarker tests that are relevant to global chronic disease are now applicable to neuropsychiatric diseases to prevent autoimmune disease, endoplasmic reticulum stress associated mitophagy with relevance to neuron apoptosis. Metabolic abnormalities has been linked to neuropsychiatric disorder with the careful nutritional assessment of patients reported in many published studies. Early interventions with genomic medicine now assist in the prevention of autoimmune disease associated with global chronic disease and neuropsychiatric disorders. Functional foods that contain appropriate doses of activators will allow modulation of neuropsychiatric diseases at the nuclear receptor level with the maintenance of neuron endoplasmic reticulum stress and the prevention of mitophagy associated with accelerated neurodegeneration.