Genetic Factors of Diabetic Nephropatia in Patients with Type 2 Diabetes Mellitus

Ozimbay Jabborov

Authors

Ozimbay Jabborov

Keywords:

diabetes mellitus, diabetic nephropathy, polygenic, genome, chronic kidney disease, genetic polymorphism

Abstract

The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.

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How to Cite

Genetic Factors of Diabetic Nephropatia in Patients with Type 2 Diabetes Mellitus. (2019). Global Journal of Medical Research, 19(F1), 1-7. https://medicalresearchjournal.org/index.php/GJMR/article/view/1676

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References

M Anciferov, L Dorofeeva (2005) Avandia (rosiglitazone) is a modern insulin sensitizer for the correction of insulin resistance in type 2 diabetes mellitus // Pharmateca. 12, 16-23.

(2003) Diabetes in Children and Adolescents. 213-217.

L Danilova (2010) Type 2 diabetes mellitus: modern approaches to correction. 34.

(2007) Determining the prognosis of the development of diabetic nephropathy in patients with type 1 diabetes mellitus based on molecular genetic studies: a guide for doctors.

T Chuck (2013) Figure 12. Distribution of complication frequencies in patients with type 1 and type 2 diabetes mellitus in the "65-" and "65+" groups based on the Database of Clinical and Epidemiological Monitoring of Diabetes Mellitus in the Russian Federation.. 3(31), 65-70.

I Yaschenko (2004) D association of the polymorphism of the angiotensin-converting enzyme gene with diabetic nephropathy in type 2 diabetes patients (residents of Chuvashia): author. 99.

Omar Ali (2013) Genetics of type 2 diabetes. 4(4), 114.

American Association Of Diabetes Educators (2008) AADE Position Statement. 35(3_suppl), 57S-59S.

(1996) A genome-wide search for human non-insulindependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 / C.L. Hanis [et al. 13, 161-166.

Michael Brownlee, Irl Hirsch (2006) Glycemic Variability: A Hemoglobin A_1c-Independent Risk Factor for Diabetic Complications. 295(14), 1707.

Z Bloomgarden (2008) Diabetic nephropathy. 31(4), 823-827.

A Gjesing, L Kjems, M Vestmar, N Grarup, A Linneberg, C Deacon, J Holst, O Pedersen, T Hansen (2011) Carriers of the TCF7L2 rs7903146 TT genotype have elevated levels of plasma glucose, serum proinsulin and plasma gastric inhibitory polypeptide (GIP) during a meal test. 54(1), 103-110.

Yukio Horikawa, Naohisa Oda, Nancy Cox, Xiangquan Li, Marju Orho-Melander, Manami Hara, Yoshinori Hinokio, Tom Lindner, Hirosato Mashima, Peter Schwarz, Laura Del Bosque-Plata, Yohko Horikawa, Yukie Oda, Issei Yoshiuchi, Susan Colilla, Kenneth Polonsky, Shan Wei, Patrick Concannon, Naoko Iwasaki, Jan Schulze, Leslie Baier, Clifton Bogardus, Leif Groop, Eric Boerwinkle, Craig Hanis, Graeme Bell (2000) Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. 26(2), 163-175.

Andrzej Krolewski (1999) Genetics of diabetic nephropathy: Evidence for major and minor gene effects. 55(4), 1582-1596.