Objective: Objective of this study was to reduce the perinatal mortality and morbidity associated with congenital anomalies by antenatal detection on grey scale ultrasound and finding their relative distribution, frequency and risk factors. Study Design: Prospective observational study. Materials and Methods: We conducted this prospective study at the Radiology department of MINAR cancer hospital Multan. All Women with congenital anomalies detected on antenatal ultrasound (USG) were included in the study. Data collected on predesigned Performa was analyzed statistically. Results: 3098 pregnant patients reported for grey scale ultrasound (USG) during the study period. Gross fetal anomalies were detected in 76 patients making the prevalence of 2.38%. The mean age and SD of patients were 25.8 years ±5.24 while the mean gestational age of the patients was 26.8weeks with SD ± 6.438. The anomalies involving the Central nervous system (CNS) were the most common of all (48.6%) followed by those of the genitourinary system (GUS) forming 13.5%. We detected twelve patients with major type of fetal anomalies seems to be non compatible with life whom we recommended for termination of pregnancy.