Functional Dietary Supplementation of Okara soybeans residue on Streptozotocin Induced Diabetes Mellitus in Male Wistar Rats

Abstract

A poor dietary habit has been demonstrated to be one of the key players in the development of diabetes mellitus and a diet rich in dietary fiber has been highlighted to be a potent candidate for the management of diabetes mellitus Therefore this study is aimed to validate the role of dietary supplementation of okara soybeans residue in streptozotocin induced diabetic male Wistar rats The total of 28 rats between the weight of 100 to 105g was grouped into four n 7 and this study spanned for a period of 43days All experimentations were conducted using standard method and our findings show that the cumulative feed intake of 15 okara diet supplementation was significantly higher p 0 05 particularly from day 29 to day 43 relative to the negative control After treatment for a period of 43days 6mg kg glibenclamide treated group 226 33 6 38 and 15 okara supplemented diet fed group 219 83 5 67 showed a significant increase p 0 05 in body weight relative to the Negative control 161 17 3 60 15 okara diet supplementation significantly lowered p 0 05 blood sugar levels after treatment relative to after induction similar to 6mg kg glibenclamide treated group Glycated hemoglobin glucose-6-phosphate dehydrogenase lipid profile CHOL TRIG LDL and HDL liver function enzymes AST ALT ALP and GGT kidney function biomarkers Creatinine Urea Sodium and potassium and antioxidant enzymes CAT SOD GSH GST and GPX were all significantly restored within the normal range Histological observations of the pancreatic liver and kidney tissue showed no visible lesion for 15 Okara supplemented diet feeding Conclusively we recommend food supplementation with Okara