Research since ancient times have claimed the therapeutic benefits of Aloe Vera in medical field. The role of Aloe Vera in reducing inflammation is already established. The recent research has thrown light on the immunomodulatory properties of Aloe Vera gel. The immunomodulatory property of Aloe Vera is attributed to the various polysaccharides present in the gel, primarily Acemannans. In this review the possible use and applications of Aloe Vera in dentistry is elaborated.