It is postulated that a suppressed or stimulated state of immune reactivity plays an important role in the induction of an infection process, which triggers the activation of microbiota pathogens. Infection-driven destruction of cells of a macroorganism promotes the release of endogenous low molecular weight nucleic acids, mostly RNA, which, within the first hours/days, are responsible for the stimulation of replication and toxin formation by microflora with subsequent disease exacerbation, and as a result, in a few days, cause an increase in antigenicity, immunogenicity, antibiotic susceptibility of pathogens, and activation of nonspecific and specific resistance of the body, with the resulting immune activation. Concurrently with these processes, the intensification of free-radical lipid and protein oxidation is observed, with the formation of immunosuppressive compounds which are neutralized by enzymatic and nonenzymatic factors of the antioxidant system. Thus, in infection processes homeostasis is achieved by means of a sequential cascade of microbial, immune, and metabolic mechanisms which induce, stimulate, and inhibit the responsiveness of the body.

How to Cite
ZEMSKOV, PRONKO, AFANASIEV, Zemskov,. Controversial Issues of Clinical Immunology. Modern Concepts about the Pathogenesis of Infections. Global Journal of Medical Research, [S.l.], dec. 2019. ISSN 2249-4618. Available at: <https://medicalresearchjournal.org/index.php/GJMR/article/view/1899>. Date accessed: 05 june 2020.

Organize Conference

We organize seminars /symposium /conferences/workshop/webinar worldwide on innovative topics and fields of Computer Science and research. We also collaborate, partner or sponsor with a view to provide our professional guidance and expertise to conduct in standard way.

Read More

Research Membership

Global Journals Inc., as described in our Corporate Statement, is an educational, research, research publishing, and professional membership organization. Elevation to the ranks of Fellow of the Association of the Research Society in Computer and Member of the Association of the Research Society in Computer is open.

Read More