Antioxidant and Cytotoxic Properties of Essential Oils from Native Brazilian Lauraceae Species

Paulo Roberto H. Moreno; Fabiana Lima Silva; Amanda Esp#xED;rito Santo; Paola Cristina Branco; Let#xED;cia Veras Costa-Lotufo; Maria Cla#xFA;dia Marx Young

Authors

Paulo Roberto H. Moreno
Fabiana Lima Silva
Amanda Esp#xED;rito Santo
Paola Cristina Branco
Let#xED;cia Veras Costa-Lotufo
Maria Cla#xFA;dia Marx Young

Keywords:

Ocotea odorifera, Ocotea indecora, Persea venosa, essential oil, biological activities

Abstract

Analysis of the leaf and stem essential oils from three Brazilian Lauraceae species showed that the major constituent of O. odorifera was safrole (57.1 and 88.5% for leaves and stems, respectively) while for O. indecora leaves the major ones were the α-pinene (12.8%) and β-pinene (12.4%) and β-bisabolol (12.2%) in the stems. For the third species, Persea venosa, the main components of leaf and stem oils were spathulenol (27.8 and 14.7%, respectively) and humulene epoxide II (11.3 and 5.1%, respectively). The bioactivity results indicated that the leaf essential oil from O. indecora was the most active for both radical scavenging activity (IC50=0.142 mg/mL) and cytotoxicity against human tumor cells, with growth inhibitions for the colon tumoral line HCT-116 (100%) and breast cancer cell line MCF-7 (99.2%), at 5 μg/mL concentration. This activity might be related to the presence of α-pinene and β-pinene in the leaf essential oil of O. indecora. However, further studies with the isolated compounds are necessary to fully understand these bioactivites.

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How to Cite

Antioxidant and Cytotoxic Properties of Essential Oils from Native Brazilian Lauraceae Species. (2020). Global Journal of Medical Research, 19(B3), 1-8. https://medicalresearchjournal.org/index.php/GJMR/article/view/1908

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