Reported case was a 68 years old Male with Earlystage Osteoarthritis of both knees (Sandhigata Vata), accompanied by reduced medial joint spaces bilaterally, marginal osteophytes. Initially, VAS scale rating was poor. Proven herbal formulations like Painmukti MJ, Painmukti Sandhical, Painmukti cream along with Advance Virechana (Arthrox), Knee Dhara, Yogbasti, and Matrabastitwice a week was given for 16months.Visual analog scale for knee pain and an Ayurveda clinical assessment criteria used to evaluate the effects of Treatment and Herbal remedies monthly basis. After a treatment of 30 days of Advance Virechana (Arthrox), Knee Dharaand Yogbasti, Pain, movement, and stability of the joint was improved at an excellent level. During follow up visit with the help of Matrabasti twice a week, Pain, movement of joint and stability, and even X-ray reading were change. In conclusion, this knee osteoarthritis patient’s quality of life improved by Advance Virechana (Arthrox).