In Vitro Antioxidant, Anti-Inflammatory And Anti-Microbial Activity of Carica Papaya Seeds

Kanthesh M Basalingappa; Pooja G. Singh; Madhu S. B; Shailasree  Sekhar; Gopenath TS; Dr. Sushma BV

Authors

Kanthesh M Basalingappa
Pooja G. Singh
Madhu S. B
Shailasree Sekhar
Gopenath TS
Dr. Sushma BV

Keywords:

carica papaya L, seed extracts, phytochemical analysis, antioxidant, lipoxygenase inhibition, antimicrobial activity

Abstract

Papaya seeds are reported to have higher therapeutic potential in comparison to the fruits in which they reside. Thus, the present in-vitro study aimed to evaluate and compare the anti-oxidant, anti-inflammatory and anti-microbial effect of seed extracts on Carica papaya L. (Caricaceae). The bioactive form the seeds were sequentially fractionated with hexane, chloroform, diethyl ether, and methanol in the increasing order of polarity. Total phenolic and flavonoid contents were estimated. These extracts were assessed for an antioxidant property by 1, 1-diphenyl-2-picryl-hydroxyl (DPPH) method and reducing power assay was carried out using the FeCl3 method. Inhibition of 15-lipoxygenase (LOX) by these extracts at 5 -25μg to asses anti-inflammatory capacity was studied.

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How to Cite

In Vitro Antioxidant, Anti-Inflammatory And Anti-Microbial Activity of Carica Papaya Seeds. (2020). Global Journal of Medical Research, 20(B2), 19-38. https://medicalresearchjournal.org/index.php/GJMR/article/view/1962

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References

(2020) Chrysin Chlorogenic acid 3-O-Caffeoylquinic acid Apigenin Hydroxybenzoic acid-O-Hexoside Rasmarinic acid Isorhamnetin-3-O-Hexoside P-MS2 In Vitro Antioxidant, Anti-Inflammatory and Anti-Microbial Activity of Carica Papaya Seeds 35 Year 2020 References Références Referencias. 279, 738.

Irfan Muhammad, Haseeb Tariq, Bilal Ghaffar, Tauqeer Ahmed, Abbas Sultan, Muhammad Muhammad, Farrukh (2015) Phytochemical and Microbiological Evaluation of Different Chemical Extracts of Papaya Seeds on Clinical Isolates. 5(1), 122-126.

F Yusha'u, Onuorah, Y Murtala (2009) In-Vitro Sensitivity Pattern of Some Urinary Tract Isolates to Carica papaya extracts. 2(2), 75-78.

D Delphin, R Haripriya, S Subi, D Jothi, Vasan Phytochemical Screening of Various Ethanolic Seed Extracts. 7(3), 1041-1048.

Sekhar Shailasree, Harishchandra Karmakarruma, Prakash (2013) Curative properties of Buchananialanzan: As evaluated by its antioxidant, anti-inflammatory and DN protective properties. 14.

Agung Lisdahayatie, Ekosuhartono Biworo (2015) Aqueous Extracts of Seed and Peel of Carica Papaya Against Aedes Aegypti. 4(4).

Chethan J, Sampath Kumara K K, Shailasreesekhar, H Prakash (2012) Antioxidant, Antibacterial and DNA Protecting Activity of Selected Medicinally Important Asteraceae Plants.

N Raaman (2015) Thin layer chromatographic analysis and Anioxidant Activities of Methanol Extract of Leaves of C.papaya. 4(2).

Ozkan Aysun, Gubbuk Hamide, Gunes Esma, Erdogan Ayse (2009) Antioxidant capacity of juice from different papaya cultivars grown under greenhouse conditions in Turkey. 35(5), 619-625.

Kaibing Zhou, Hui Wang, Wenli Mei, Xiaona Li, Ying Luo, Haofu Dai (2011) Antioxidant Activity of Papaya Seed Extracts. 16(8), 6179-6192.

Sampath-Kumara Shailasreesekhar, Niranjana Kk, H S Prakash (2013) In Vitro Antioxidant Activity, Lipoxygenase Cyclooxygenase-2 Inhibition and DNA Protection Properties of memecylonspecies. 5(2), 257-262.

E Okoye (2011) Preliminary phytochemical analysis and antimicrobialActivity of seeds of Carica papaya.

Augustine Ocloo, Constance Nonye, Nicholas Nwokolo, Dayie (2012) Phytochemical Characterization and Comparative efficacies of crude extracts of carica papaya. 2(5), 399-406.

Shailasreesekhar Tumkurramasettybharathi (2016) Kiggakadappasampath kumara, Mudalabeeduchandregowda, Madhusudhanand Harishchandra sripathy Prakash. 6(4), 225-231.

K Sekhar Shailasree, S Sampathkumara, H Niranjana, Prakash (2014) Bioactive Potential of Medicinal Plants from Western Ghats Region, India. 20, 221-234.

Onkar Singh, M Ali (2011) Phytochemical and Antifungal Profiles of the Seeds of Carica Papaya L. 73(4), 447-451.

D Kubmarawa, G Ajoku, M Enworem, D Okorie (2007) Preliminary phytochemical and antimicrobial screening of 50 medicinal plants from Nigeria. 6, 1690-1696.

Sumitra Jigna (2007) Antibacterial activity and phytochemical screening of some medicinal plants commonly used in Saudi Arabia against selected pathogenic microorganisms. 25(2), 115-120.

N Lohiya, R B Goyal, D Jayaprakash, A Ansari, S Sharma (1994) Antifertility effects of aqueous extract of Carica papaya seeds in male rats. 60(5), 400-404.

Paul Udoh, Itohowo Essien, Francis Udoh (2005) Effects ofCarica papaya (paw paw) seeds extract on the morphology of pituitary-gonadal axis of male Wistar rats. 19(12), 1065-1068.

R J Verma, Deepa Nambiar, N Chinoy (2006) Toxicological effects of Carica papaya seed extract on spermatozoa of mice. 26(6), 533-535.

V Boshra, A Tajul (2013) Papaya -an innovative raw material for food and pharmaceutical processing industry. (4).

A Rezaeizadeh, A Zuki, Abdollahi, Y Goh, M Noordin, M Hamid, T (2011) Antibacterial Activity of Crude Momordica charantia, Cassia alata, and Allium sativum Methanolic Extracts on Leptospira interrogans serovar Manilae. 10(24), 4932-4940.

Charles Boning (2006) BIOLOGICAL COMMUNITIES OF NORTH FLORIDA. xxi-xxiv.

K Kovendan, K Murugan, C Panneerselvam, N Aarthi (2012) Antimalarial activity of carica papaya leaf extract against plasmodium falciparum. 306-S311.

G Trease, W Evans (1989) Unknown Title. 11, 45-50.

P Akah, A Oli, N Enwerem, K Gamaniel (1997) Preliminary studies on purgative effect of Carica papaya root extract. 68(4), 327-331.

Ayoola (2008) Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants. 7(3), 1019-1024.