Background: Histological diagnoses of endoscopic biopsies are keys to improved outcomes of patient management; hence endoscopy and histological evaluation of the associated specimens are agelong practices globally, but this practice is just evolving in Port Harcourt. Aim: To characterize the clinico-pathologic features of gastric endoscopic biopsies seen in Port Harcourt. Methodology: This is a retrospective study of gastric endoscopic biopsies seen in a private pathology referral practice in Port Harcourt between 1st January 2014 and 31st December 2018. The relevant clinical and demographic information were obtained from patients’ laboratory request forms. The gastric biopsies were fixed in 10% neutral buffered formalin, processed, and stained with hematoxylin and eosin for general morphology. Modified Giemsa stain was used for Helicobacter pylori identification. The slides were reported using the updated Sydney classification.