Abstract

Probiotic bacteria which are traditionally studied to aid intestinal functions are also currently being researched for benefits in other parts of the body such as the oral cavity In the case of throat infections caused by bacteria which traditional treatment involves antibiotics some researchers are studying the possibility of introducing special strains of commensal bacteria into the mouth that can specifically inhibit the tonsillitis agent Streptococcus pyogenes for both prevention and treatment of such disease A PCR assay was used to identify Streptococcus salivarius subsp salivarius Therefore tests for the complete absence of toxicity of these strains are required to ensure their safe use in human trials In this research we evaluated the new Streptococcus salivarius subsp salivarius BIO5 strain for toxicity factors as follows clinical ophthalmic lesions behavioral observations mortality anatomopathological examination biopsy hematology serum biochemistry and urine analysis This strain isolated from the oral cavity and with bacteriocinogenic activity against S pyogenes showed a complete absence of toxicity and thus it may be used in replacement therapy as a probiotic