Abstract

Dyslipidemia is one of the major derrangement observed in type 2 diabetes mellitus which further leads to various life threatening complications. Certain herbal disulphides/thiols are known to cater a solution towards regulation of this diabetes mellitus induced dyslipidemia. It is known that Diallyl Disulphide (DADS), a component of garlic extract possess hypolipidemic activities and may have therapeutic applications, but the metabolite of DADS, acrolein is toxic and poses certain disadvantages. Certain modified /altered disulphides, shown to possess significant hypolipidemic action with lesser toxic effects. In the present study, we tried to establish the hypolipidemic activities of Diaceto-Dipropyl-Disulphide (DADPDS), a synthetic modified disulphide in alloxan diabetic rats. The results show a significant decrease in plasma cholesterol (60%), plasma triacylglycerol (42%), liver tissue cholesterol (41%) and liver tissue triacylglycerol (23%),indicating the usefulness of this modified disulphide in controlling diabetes induced dyslipidemia.