Abstract

The present proniosomal gel investigation was aimed to minimize the adverse effects associated with present topical butenafine hydrochloride formulations and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system Butenafine hydrochloride is an allylamine class of advanced antifungal drug Which mainly recommended to treat long term topical fungal infection Proniosomes were prepared by slurry method using different concentrations of non-ionic surfactant span and tween and evaluated various parameter like surface morphology entrapment efficiency drug content viscosity drug content in-vitro drug release in-vitro fungal activity and stability studies The results showed that formulation F3 containing span 60 cholesterol 1 2 showed highest drug content 99 13 and entrapment efficiency 79 87 compared to other formulations The pH and viscosity of prepared all proniosomal gel formulation were found in range 5 40-6 11 and 8920-14400CPs correspondingly